<strong>Metastability demystified — the foundational past, the pragmatic present, and the potential future</strong>

Опубликована: Июль 21, 2023

Healthy brain functioning depends on balancing stable integration between areas for effective coordinated functioning, with bursts of desynchronisation to allow subsystems reconfigure and express functional specialisation. Metastability, a concept originated in statistical physics dynamical systems theory, has been proposed as key signature that characterises this balance. Building principle, the neuroscience literature employed markers metastability investigate various aspects function including cognitive performance, healthy ageing, meditation, sleep, responses pharmacological challenges, characterise psychiatric conditions or disorders consciousness. However, body work often uses notion heuristically, sometimes inaccurately, making it hard uninitiated navigate vast literature, interpret findings, foster further development theoretical experimental methodologies. In paper we provide comprehensive review its applications neuroscience, covering scientific historical foundations practical estimators used estimate empirical data. We also critical analysis recent developments, clarifying common misconceptions paving road future developments.

Язык: Английский

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Biophysical modulation and robustness of itinerant complexity in neuronal networks

Frontiers in Network Physiology, Год журнала: 2024, Номер 4

Опубликована: Март 7, 2024

Transient synchronization of bursting activity in neuronal networks, which occurs patterns metastable itinerant phase relationships between neurons, is a notable feature network dynamics observed vivo . However, the mechanisms that contribute to this dynamical complexity circuits are not well understood. Local cortical regions consist populations neurons with diverse intrinsic oscillatory features. In study, we numerically show phenomenon transient synchronization, also referred as metastability, can emerge an inhibitory population when neurons’ fast-spiking appropriately modulated by slower inputs from excitatory population. Using compact model mesoscopic-scale consisting pyramidal and our work demonstrates relationship frequency oscillations features emergent metastability addition, introduce method characterize collective transitions networks. Finally, discuss potential applications study mechanistically understanding dynamics.

Язык: Английский

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Multiscale synchronisation dynamics reveals the impact of an improvisatory approach to performance on music experience

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 24, 2025

Abstract Experiences of collective creative activities play an essential role in human societies, yet these experiences are particularly hard to capture, making their scientific study challenging. In a classical music concert-experiment performed by string quartet, we contrast Let-go performance mode, characterised more and improvisatory approach that encourages risk-taking spontaneous expression, with Strict mode which requires adhering closely the score, common many Western environments. We investigate experience audience members analysing subjective reports movement patterns. Our results show during performances synchronization was reduced between performers shorter timescales, while its temporal variability were enhanced longer timescales. Furthermore, differences dynamics predictive changes audience’s perception music. These provide first step towards quantification some fundamental aspects experiences. Specifically, reported findings demonstrate relevance often-neglected multiscale coordination audiences performers, explain how this rich tapestry physical behaviour is connected quality experience.

Язык: Английский

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Mathematical Modeling of Transient Dynamics in Electroencephalography Using Data Assimilation Methods

The Brain & Neural Networks, Год журнала: 2025, Номер 32(1), С. 22 - 29

Опубликована: Март 5, 2025

Язык: Английский

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Emergence of metastability in frustrated oscillatory networks: the key role of hierarchical modularity

Frontiers in Network Physiology, Год журнала: 2024, Номер 4

Опубликована: Авг. 21, 2024

Oscillatory complex networks in the metastable regime have been used to study emergence of integrated and segregated activity brain, which are hypothesised be fundamental for cognition. Yet, parameters underlying mechanisms necessary achieve hard identify, often relying on maximising correlation with empirical functional connectivity dynamics. Here, we propose show that brain’s hierarchically modular mesoscale structure alone can give rise robust dynamics (metastable) chimera states presence phase frustration. We construct unweighted 3-layer hierarchical identical Kuramoto-Sakaguchi oscillators, parameterized by average degree network a structural parameter determining ratio connections between within blocks upper two layers. Together, these affect characteristic timescales system. Away from critical synchronization point, detect lowest layer coexisting Using Laplacian renormalization group flow approach, uncover distinct pathways towards achieving regimes detected In layers, how symmetry-breaking depend slow eigenmodes instead, achieved as separation layers reaches threshold. Our results an explicit relationship metastability, states, system, bridging gap harmonic based studies data oscillatory models.

Язык: Английский

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Unifying biophysical consciousness theories with MaxCon: maximizing configurations of brain connectivity

Frontiers in Systems Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Июль 29, 2024

There is such a vast proliferation of scientific theories consciousness that it worrying some scholars. are even competitions to test different theories, and the results inconclusive. Consciousness research, far from converging toward unifying framework, becoming more discordant than ever, especially with respect theoretical elements do not have clear neurobiological basis. Rather dueling an integration across needed facilitate comprehensive view on how normal nervous system dynamics can develop into pathological states. In dealing what considered extremely complex matter, we try adopt perspective which subject appears in relative simplicity. Grounded experimental observations, advance encompassing biophysical theory, MaxCon, incorporates aspects several main existing neuroscientific finding convergence points attempt simplify understand cellular collective activity organized fulfill dynamic requirements diverse our proposal comprises. Moreover, computable index indicating level presented. Derived description interactions among cell networks, highlights association maximization number configurations neural network connections -constrained by neuroanatomy, biophysics environment- common all theories.

Язык: Английский

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The physiology of coordination: self‐resolving diverse affinities via the sparse order in relevant noise

The Journal of Physiology, Год журнала: 2023, Номер 602(11), С. 2581 - 2600

Опубликована: Дек. 27, 2023

Living systems at any given moment enact a very constrained set of end-directed and contextually appropriate actions that are self-initiated from among innumerable possible alternatives. However, these not necessarily because the system has reduced its sensitivities to themselves their surroundings. Quite contrary, living continually open novel unanticipated stimulations require physiology coordination. To address competing demands, this paper offers heuristic model informed by neuroscience, theory, biology sign study explain how organisms situated in diverse, complex ever-changing environments might draw upon sparse order made available 'relevant noise'. This emergent facilitates coordination, habituation and, ultimately, understanding world relevant affordances. Inspired burgeoning field coordination dynamics physiologist Denis Noble's concept 'biological relativity', proposes view on neuronal level is neither sequential nor stochastic, but instead implements causal logic phasic alignment, such an organism's learned inherited sets diverse biological affinities sympathies can be resolved into continuous range patterns will implement kind orientations radical generativity required adaptively explore learn experiences.

Язык: Английский

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Laughter as a subject and a tool for interdisciplinary investigations in Philosophy and Neuroscience

Authorea (Authorea), Год журнала: 2024, Номер unknown

Опубликована: Июль 31, 2024

Laughter has been studied by both philosophers and neuroscientists, yet the possible bridges between these two fronts of investigation is little explored.Bergson theorized about laughter argued its central social role.Human laughter, for Bergson, needs a echo brings malleability to rigidity.We laugh, instance, at what mechanical where there should be flexibility.Critchley, contemporary philosopher, agrees with Bergson adds that humor also can change our views on structures situations.Based philosophical theories recent methodological advances in functional connectivity dynamics neuroimaging, we advance an hypothesis relations cognitive flexibility brain metastability.Laughter interpreted as behavior reframes interaction context modulates individuals instantiating flexibility.Finally, alongside curiosity, argue not only subject but tool advancing neuroscience.

Язык: Английский

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Metastable Dynamics Emerge from Local Excitatory-Inhibitory Homeostasis in the Cortex at Rest

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 26, 2024

The human cortex displays highly metastable dynamics at rest, underlying the spontaneous exploration of large-scale network states. This metastability depends on edge-of-bifurcation circuit level, which emerge due to local control firing rates through multiple mechanisms excitatory-inhibitory (E-I) homeostasis. However, it is unclear how distinct forms homeostasis contribute cortical networks. Here, we propose that individual E-I uniquely emergence and resting-state functional networks test hypothesis in a model cortex. We show empirical can only be reproduced when accounting for More specifically, while excitation inhibition enhances metastability, complementary regulation intrinsic excitability ensures moderate levels synchrony, maximizing complexity Furthermore, modulation distance-to-bifurcation by supports collective compensating strong input fluctuations strongly connected areas. Altogether, our results self-organize toward maximal multi-factor homeostatic balance, controls dynamics. Therefore, benefits combining transcend supporting rich Significance Statement Experimental studies have consistently shown circuits maintain precise thereby optimizing While well-established are involved this regulation, remains each contributes study presents evidence that, homeostasis, towards regime complex Crucially, demonstrate from synergistic action mechanisms. Our findings advance understanding as process self-organization, demonstrating its key role maintenance

Язык: Английский

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Laughter as a subject and a tool for interdisciplinary investigations in Philosophy and Neuroscience

Authorea (Authorea), Год журнала: 2024, Номер unknown

Опубликована: Авг. 29, 2024

Laughter has been studied by both philosophers and neuroscientists, yet the possible bridges between these two fronts of investigation is little explored.Bergson theorized about laughter argued its central social role.Human laughter, for Bergson, needs a echo brings malleability to rigidity.We laugh, instance, at what mechanical where there should be flexibility.Critchley, contemporary philosopher, agrees with Bergson adds that humor also can change our views on structures situations.Based philosophical theories recent methodological advances in functional connectivity dynamics neuroimaging, we advance an hypothesis relations cognitive flexibility brain metastability.Laughter interpreted as behavior reframes interaction context modulates individuals instantiating flexibility.Finally, alongside curiosity, argue not only subject but tool advancing neuroscience.

Язык: Английский

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