medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 9, 2023
ABSTRACT
We
examined
changes
in
large-scale
functional
connectivity
and
temporal
dynamics
their
underlying
mechanisms
schizophrenia
(ScZ)
through
measurements
of
resting-state
magnetic
resonance
imaging
(rs-fMRI)
data
computational
modelling.
The
rs-fMRI
from
patients
with
chronic
ScZ
(n=38)
matched
healthy
controls
(n=43),
were
obtained
the
public
schizConnect
repository.
Computational
models
constructed
based
on
diffusion-weighted
MRI
scans
fit
to
experimental
data.
found
decreased
across
sensory
association
areas
for
all
subnetworks
group.
Additionally
global
synchrony
was
reduced
while
metastability
unaltered.
Perturbations
model
revealed
that
coupling
increased
background
noise
levels
both
explained
experimentally
deficits
better
than
local
GABAergic
or
glutamatergic
system.
current
study
suggests
alterations
are
more
likely
result
rather
network
changes.
Entropy,
Год журнала:
2024,
Номер
26(12), С. 1048 - 1048
Опубликована: Дек. 3, 2024
Entropy
management,
central
to
the
Free
Energy
Principle,
requires
a
process
that
temporarily
shifts
brain
activity
toward
states
of
lower
or
higher
entropy.
Metastable
synchronization
is
by
which
system
achieves
entropy
fluctuations
intermittently
transitioning
between
collective
order
and
disorder.
Previous
work
has
shown
oscillations,
similar
those
recorded
from
brain,
emerge
spontaneously
weakly
stable
in
critically
coupled
oscillator
systems.
However,
direct
evidence
linking
formation
oscillations
lacking.
In
this
short
communication,
we
demonstrate
how
emergence
Oscillatory
Modes
(MOMs)
directly
associated
with
temporary
reduction
ongoing
dynamics.
We
apply
Shannon
distribution
eigenvalues
phase
covariance
over
sliding
time
windows,
capturing
temporal
evolution
at
level
entire
dynamical
system.
By
demonstrating
MOMs
impacts
system’s
levels,
bridge
theoretical
works
on
physics
oscillators
FEP
framework,
supporting
hypothesis
rhythms
experimentally
are
signature
management.
There
is
such
a
vast
proliferation
of
scientific
theories
consciousness
that
it
worrying
some
scholars.
are
even
competitions
to
test
different
theories,
and
the
results
inconclusive.
Consciousness
research,
far
from
converging
toward
unifying
framework,
becoming
more
discordant
than
ever,
especially
with
respect
theoretical
elements
do
not
have
clear
neurobiological
basis.
Rather
duelling
an
integration
across
needed
tofacilitate
comprehensive
view
on
how
normal
nervous
system
dynamics
can
develop
into
pathological
states.
In
dealing
what
considered
extremely
complex
matter,
we
try
adopt
perspective
which
subject
appears
in
relative
simplicity.
Grounded
experimental
observations,
advance
encompassing
biophysical
theory,
MaxCon,
incorporates
aspects
several
main
existing
neuroscientific
finding
convergence
points
attempt
simplify
understand
cellular
collective
activity
organized
fulfill
dynamic
requirements
diverse
our
proposal
comprises.
Moreover,
computable
index
indicating
level
presented.
Derived
description
interactions
among
cell
networks,
highlights
association
maximisation
number
configurations
neural
network
connections
-constrained
by
neuroanatomy,
biophysics
environment―
common
all
theories.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 9, 2023
ABSTRACT
We
examined
changes
in
large-scale
functional
connectivity
and
temporal
dynamics
their
underlying
mechanisms
schizophrenia
(ScZ)
through
measurements
of
resting-state
magnetic
resonance
imaging
(rs-fMRI)
data
computational
modelling.
The
rs-fMRI
from
patients
with
chronic
ScZ
(n=38)
matched
healthy
controls
(n=43),
were
obtained
the
public
schizConnect
repository.
Computational
models
constructed
based
on
diffusion-weighted
MRI
scans
fit
to
experimental
data.
found
decreased
across
sensory
association
areas
for
all
subnetworks
group.
Additionally
global
synchrony
was
reduced
while
metastability
unaltered.
Perturbations
model
revealed
that
coupling
increased
background
noise
levels
both
explained
experimentally
deficits
better
than
local
GABAergic
or
glutamatergic
system.
current
study
suggests
alterations
are
more
likely
result
rather
network
changes.
