GPI-anchored serine proteases: essential roles in development, homeostasis, and disease
Joseph G. Lundgren,
Michael G. Flynn,
Karin List
и другие.
Biological Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 17, 2025
Abstract
The
glycosylphosphatidylinositol
(GPI)-anchored
serine
proteases,
prostasin
and
testisin,
have
essential
roles
in
diverse
physiological
functions
including
development,
reproduction,
homeostasis
barrier
function
of
epithelia,
angiogenesis,
coagulation,
fibrinolysis.
Important
pathological
conditions
such
as
cancer,
kidney
disease
cardiovascular
also
been
reported.
In
this
review,
we
summarize
current
knowledge
the
cellular
vivo
testisin
physiology
pathophysiology
explore
underlying
molecular
mechanisms.
We
discuss
how
new
insights
their
role
cancer
may
facilitate
translation
into
clinical
settings
future.
Язык: Английский
Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity
Опубликована: Авг. 14, 2023
The
serine
proteases
CAP1/Prss8
(prostasin)
and
CAP3/St14
(matriptase)
are
identified
as
ENaC
channel-activating
in
vitro
highly
suggesting
that
they
required
for
proteolytic
activation
of
vivo.
present
study
tested
whether
CAP3
is
relevant
renal
affects
ENaC-mediated
Na+
absorption
following
Na+-deprivation
conditions.
knockout
mice
exhibit
significant
decrease
CAP1
protein
expression
with
altered
subunit
decreased
pNCC
abundances,
but
overall
maintain
sodium
balance.
RNAscope-based
analyses
reveal
co-expression
alpha
distal
tubules
the
cortex
from
wildtype
mice.
Double
CAP1/CAP3-deficiency
maintained
K+
balance
on
Na+-deprived
diet,
restored
abundances
showed
reduced
NCC
activity
under
Na+-deprivation.
Overall,
our
data
clearly
show
not
direct
ENaC,
its
abundances.
Our
a
complex
regulation
by
these
level
rather
than
activation.
Язык: Английский