COVID-19 Outcomes in Kidney Transplant Recipients in a German Transplant Center DOI Open Access
Michael Mikhailov, Klemens Budde,

Fabian Halleck

и другие.

Опубликована: Авг. 15, 2023

Kidney transplant recipients (KTR) show higher morbidity and mortality from COVID-19 than the general population have an impaired response to vaccination. We analyzed incidence clinical outcomes in a single-center cohort of approximately 2500 KTR. Between February 1, 2020 July 2022, 578 KTR were infected with SARS-CoV-2, 25 (4%) recurrent infections. 208 (36%) hospitalized, 39 (7%) died. Among vaccinated patients, infection Omicron variant had 2%. Unvaccinated patients showed (9% vs. 11%) (hospitalization 52% 54%, ICU-admission 12% 18%) comparable pre-Omicron era. Multivariable analysis revealed, being unvaccinated (OR = 2.15, 95% CI [1.38, 3.35]), era 3.06, [1.92, 4.87]), patient age 1.04, [1.03, 1.06]) are independent risk factors for hospitalization, whereas steroid-free immunosuppressive regimen was found reduce hospitalization 0.51, [0.33, 0.79]). This suggests that both, virological changes vaccination, Our data extend knowledge provide important insights into outcome during

Язык: Английский

Efficacy and safety of COVID-19 vaccination in solid organ transplant recipients: A systematic review and network meta-analysis DOI Creative Commons
Daniel Rayner, Jairo Tavares Nunes, David Gou

и другие.

American Journal of Transplantation, Год журнала: 2024, Номер 24(12), С. 2269 - 2281

Опубликована: Авг. 1, 2024

The impact of COVID-19 vaccination on clinical outcomes in solid organ transplant (SOT) recipients remains unclear. This systematic review and network meta-analysis sought to assess the efficacy safety SOT recipients. We searched 6 databases from inception March 1, 2024 for randomized controlled trials (RCTs) observational studies evaluating different strategies Based patient-important outcomes, we performed frequentist random-effects pairwise meta-analyses meta-analyses, separating RCTs nonrandomized evidence, used Grading Recommendation, Assessment, Development, Evaluation approach our certainty evidence. included (N = 814) 43 125 199). Overall, there is a paucity evidence vaccines including infection, mortality, hospitalization, ICU admission, rejection, demonstrated low very due studies' risk bias. Throughout pandemic, clinicians worked with minimal, low-quality relation this population. In instance future public health emergencies, researchers should collaborate closely patient partners ensure sufficient population outcomes.

Язык: Английский

Процитировано

5
COVID-19 Outcomes in Kidney Transplant Recipients in a German Transplant Center DOI Open Access
Michael Mikhailov, Klemens Budde,

Fabian Halleck

и другие.

Опубликована: Авг. 15, 2023

Kidney transplant recipients (KTR) show higher morbidity and mortality from COVID-19 than the general population have an impaired response to vaccination. We analyzed incidence clinical outcomes in a single-center cohort of approximately 2500 KTR. Between February 1, 2020 July 2022, 578 KTR were infected with SARS-CoV-2, 25 (4%) recurrent infections. 208 (36%) hospitalized, 39 (7%) died. Among vaccinated patients, infection Omicron variant had 2%. Unvaccinated patients showed (9% vs. 11%) (hospitalization 52% 54%, ICU-admission 12% 18%) comparable pre-Omicron era. Multivariable analysis revealed, being unvaccinated (OR = 2.15, 95% CI [1.38, 3.35]), era 3.06, [1.92, 4.87]), patient age 1.04, [1.03, 1.06]) are independent risk factors for hospitalization, whereas steroid-free immunosuppressive regimen was found reduce hospitalization 0.51, [0.33, 0.79]). This suggests that both, virological changes vaccination, Our data extend knowledge provide important insights into outcome during

Язык: Английский

Процитировано

2