Peptide-Hydrogel Nanocomposites for Anti-Cancer Drug Delivery
Gels,
Год журнала:
2023,
Номер
9(12), С. 953 - 953
Опубликована: Дек. 4, 2023
Cancer
is
the
second
leading
cause
of
death
globally,
but
conventional
anticancer
drugs
have
side
effects,
mainly
due
to
their
non-specific
distribution
in
body
both
cancerous
and
healthy
cells.
To
address
this
relevant
issue
improve
efficiency
drugs,
increasing
attention
being
devoted
hydrogel
drug-delivery
systems
for
different
kinds
cancer
treatment
high
biocompatibility
stability,
low
ease
modifications.
therapeutic
provide
multi-functionality,
types
nanoparticles
(NPs)
can
be
incorporated
within
hydrogels
form
smart
nanocomposites,
benefiting
advantages
counterparts
suitable
advanced
applications.
Despite
many
papers
on
non-peptide
there
limited
knowledge
about
peptide-based
specifically
anti-cancer
drug
delivery.
The
aim
short
comprehensive
review
is,
therefore,
focus
synergies
resulting
from
combination
NPs
with
hydrogels.
This
review,
which
includes
a
survey
recent
advances
kind
material,
does
not
an
exhaustive
technology,
it
instead
highlights
noteworthy
publications
discusses
novel
perspectives
valuable
insights
into
promising
synergic
peptide
design
delivery
systems.
Язык: Английский
Biocompatible Anisole-Nonlinear PEG core-shell Nanogels for High Loading Capacity, Excellent Stability, and Controlled Release of Curcumin
Опубликована: Авг. 30, 2023
Curcumin,
a
nontoxic
and
cheap
natural
medicine,
has
high
therapeutic
efficacy
for
many
diseases
including
diabetes
cancers.
Unfortunately,
its
exceedingly
low
water-solubility
rapid
degradation
in
the
body
severely
limit
bioavailability.
In
this
work,
we
prepare
series
of
biocompatible
poly(vinyl
anisole)@nonlinear
poly(ethylene
glycol)
(PVAS@PEG)
core-shell
nanogels
with
different
PEG
gel
shell
thickness
to
provide
water
solubility,
good
stability,
controllable
sustained
release
curcumin.
The
PVAS
nanogel
core
is
designed
attract
store
curcumin
molecules
drug
loading
capacity
hydrophilic
nonlinear
offer
dispersibility
thermo-responsive
release.
obtained
are
monodispersed
spherical
shape
clear
morphology.
size
can
be
easily
controlled
by
changing
precursor
feeding
ratios.
optimized
PVAS@PEG
display
38.0
wt%.
stabilize
from
at
pH
=7.4
response
heat
physiologically
important
temperature
range.
enter
cells
effectively
exhibit
negligible
cytotoxicity
both
B16F10
HL-7702
concentration
up
2.3
mg/mL.
Such
have
great
potential
used
delicate
delivery.
Язык: Английский