Novel insights into the molecular mechanisms governing embryonic epicardium formation

Опубликована: Окт. 9, 2023

The embryonic epicardium originates from the proepicardium, an extracardiac primordium constituted by a cluster of mesothelial cells. In early embryos, is characterized squamous cell epithelium resting on myocardium surface. Subsequently, it invades subepicardial space and thereafter means epithelial-mesenchymal transition. Within myocardium, epicardial-derived cells present multilineage potential, later differentiating into smooth muscle contributing both to coronary vasculature cardiac fibroblasts in mature heart. Over last decades, we have progressively increased our understanding those cellular molecular mechanisms driving proepicardial/embryonic formation. This study provides state-of-the-art review transcriptional emerging post-transcriptional involved formation differentiation epicardium.

Язык: Английский

Deciphering the Involvement of the Epicardium in Cardiac Diseases

Hearts, Год журнала: 2023, Номер 4(4), С. 81 - 93

Опубликована: Ноя. 10, 2023

The epicardium is a very dynamic cardiac layer with pivotal contributions during cardiogenesis, acting in the postnatal period as an apparently dormant single-cell layer. In mammalian embryos, epicardium, which originates form proepicardium, translocates into pericardial cavity and subsequently rests on surface of myocardium. Later, it gives rise to epicardium-derived cells, migrate subepicardial space, invade developing myocardium, promoting its growth, contribute different cell types. Anomalies process epicardial development, generation cells their signaling mechanisms experimental models lead defective reminiscent human congenital heart diseases. Furthermore, recent studies have reported that derivates adults, i.e., adipose tissue, are associated electrophysiological cardiovascular anomalies. Herein, we provide state-of-the-art review focusing both adult diseases development.

Язык: Английский