Cow’s Milk Bioactive Molecules in the Regulation of Glucose Homeostasis in Human and Animal Studies DOI Creative Commons
Emad Yuzbashian,

Emily Vanden Berg,

Stepheny C. de Campos Zani

и другие.

Foods, Год журнала: 2024, Номер 13(17), С. 2837 - 2837

Опубликована: Сен. 6, 2024

Obesity disrupts glucose metabolism, leading to insulin resistance (IR) and cardiometabolic diseases. Consumption of cow’s milk other dairy products may influence metabolism. Within the complex matrix milk, various carbohydrates, lipids, peptides act as bioactive molecules alter human Here, we summarize data from studies rodent experiments illustrating how these regulate homeostasis, supplemented with in vitro mechanisms behind their effects. Bioactive including lactose, galactose, oligosaccharides, generally reduce hyperglycemia, possibly by preventing gut microbiota dysbiosis. Milk-derived lipids fat globular membrane improve activation signaling pathways animal trials but seem have little impact on glycemia studies. However, produced ruminants, polar odd-chain, trans-, branched-chain fatty acids, produce neutral or contradictory effects derived whey casein exert both directly through insulinotropic renin-angiotensin-aldosterone system inhibition indirectly regulation incretin hormones. Overall, results bolster many observational humans suggest that intake reduces risk of, can perhaps be used treating, metabolic disorders. action for most compounds are still largely undiscovered.

Язык: Английский

Chemical Analysis and Antioxidant Activities of Resin Fractions from Pistacia lentiscus L. var. Chia in Neuroblastoma SH-SY5Y Cells DOI Creative Commons

Achilleas Georgantopoulos,

Foteini D. Kalousi,

Federica Pollastro

и другие.

Molecules, Год журнала: 2025, Номер 30(5), С. 997 - 997

Опубликована: Фев. 21, 2025

Chios mastiha is the natural aromatic resin of Pistacia lentiscus L. var. Chia, Anacardiaceae, which exclusively cultivated in southern part Greek island Chios. (P. lenticonus/Chios mastiha) well-known for its distinctive taste and aroma has been known since ancient times due to healing properties gastrointestinal inflammatory disorders because anti-bacterial anti-fungal activities. In this study, chemical composition, applying LC-QTOF-MS/MS analysis, antioxidant activities three different polarity P. fractions, apolar, medium polar, were characterized human neuroblastoma SH-SY5Y cells. Chemical analysis fractions unveiled new components mastiha, mainly fatty acids compounds, their activity regulatory effects on lipid metabolism. By MTT assay confocal microscopy we showed that especially apolar polar enriched triterpenes acids, caused suppression H2O2-induced reduction cell viability, ROS production, depolarization mitochondrial membrane potential, Moreover, Western blot revealed fraction, induced expression PPARα, crucial role Induction a GR target gene, was also accompanied by an increase protein levels. Enhanced fraction may be correlated with triterpenoids. Thus, our results indicate neuroprotective actions highlighting potential application as agents neurodegenerative diseases.

Язык: Английский

Процитировано

0
Aging-Associated Amyloid-β Plaques and Neuroinflammation in Bottlenose Dolphins (Tursiops truncatus) and Novel Cognitive Health-Supporting Roles of Pentadecanoic Acid (C15:0) DOI Open Access
Stephanie Venn‐Watson, Eric D. Jensen

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3746 - 3746

Опубликована: Апрель 16, 2025

There is an urgent need to identify interventions that broadly target aging-related cognitive decline and progression Alzheimer’s disease (AD). Bottlenose dolphins (Tursiops truncatus) have histologic changes similar AD in humans, they also develop shared age-associated co-morbidities identified as risk factors for including type 2 diabetes, ferroptosis, iron overload, which can be driven by nutritional C15:0 deficiency. We hypothesized (1) would amyloid beta (Aβ) plaques neuroinflammation paralleled of humans relation age-related progression, quantitative concentration, brain region; (2) dose-dependent activities relevant protecting health. Quantitative immunohistochemistry staining was used assess 68 tissues from archived brains 19 Navy evaluate associations among region, sex, age group. Further, activities, using a third-party panel intended screen potential therapeutics, were evaluated. Similar had the highest Aβ plaque density variation hippocampus (90th percentile 4.95 plaques/mm2), where increased with (p = 0.05). All measured markers detected, concentrations activated microglia (CD68+) (0.46 ± 0.38 cells/mm2). inhibitor two targets, fatty acid amide hydrolase (FAAH) (IC50 2.5 µM, 89% maximum inhibition at 50 µM relative URB597) monoamine oxidase B (MAO-B) 19.4 70% R(-)-Deprenyl). These demonstrated efficacy against formation neuroinflammation, protection function hippocampus. findings suggest that, addition co-morbidities, may play distinct role supporting health, especially higher concentrations.

Язык: Английский

Процитировано

0
Pentadecanoic Acid (C15:0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds DOI Open Access
Stephanie Venn‐Watson, Nicholas J. Schork

Опубликована: Окт. 9, 2023

Pentadecanoic acid (C15:0) is an essential odd-chain saturated fatty with broad activities relevant to protecting cardiometabolic, immune, and liver health. C15:0 activates AMPK inhibits mTOR, both of which are core components the human longevity pathway. To assess potential for enhance processes associated healthspan, we used cell-based molecular phenotyping assays compare three longevity-enhancing candidates: acarbose, metformin, rapamycin. (n=36 in 10 12 cell systems) rapamycin (n=32 had most clinically relevant, dose-dependent activities. At their optimal doses, (17 µM) (9 shared 24 across systems, including anti-inflammatory (e.g., lowered MCP-1, TNFɑ, IL-10, IL-17A/F), antifibrotic, anticancer activities, further supported by previously published vitro vivo studies. Paired prior demonstrated abilities target pathways, hallmarks aging, aging rate biomarkers, type 2 diabetes, heart disease, cancer, nonalcoholic our results support as nutrient equivalent to, or surpassing, leading candidate compounds.

Язык: Английский

Процитировано

4
Cow’s Milk Bioactive Molecules in the Regulation of Glucose Homeostasis in Human and Animal Studies DOI Creative Commons
Emad Yuzbashian,

Emily Vanden Berg,

Stepheny C. de Campos Zani

и другие.

Foods, Год журнала: 2024, Номер 13(17), С. 2837 - 2837

Опубликована: Сен. 6, 2024

Obesity disrupts glucose metabolism, leading to insulin resistance (IR) and cardiometabolic diseases. Consumption of cow’s milk other dairy products may influence metabolism. Within the complex matrix milk, various carbohydrates, lipids, peptides act as bioactive molecules alter human Here, we summarize data from studies rodent experiments illustrating how these regulate homeostasis, supplemented with in vitro mechanisms behind their effects. Bioactive including lactose, galactose, oligosaccharides, generally reduce hyperglycemia, possibly by preventing gut microbiota dysbiosis. Milk-derived lipids fat globular membrane improve activation signaling pathways animal trials but seem have little impact on glycemia studies. However, produced ruminants, polar odd-chain, trans-, branched-chain fatty acids, produce neutral or contradictory effects derived whey casein exert both directly through insulinotropic renin-angiotensin-aldosterone system inhibition indirectly regulation incretin hormones. Overall, results bolster many observational humans suggest that intake reduces risk of, can perhaps be used treating, metabolic disorders. action for most compounds are still largely undiscovered.

Язык: Английский

Процитировано

1