Biomedicines, Год журнала: 2024, Номер 12(11), С. 2568 - 2568
Опубликована: Ноя. 9, 2024
The biosafety of gene therapy products remains a major challenge to their introduction into the clinic. In particular, problem immunogenicity viral vectors is focus attention. Large animals such as pigs, whose anatomical and physiological characteristics are similar those humans, have an advantage in testing vector systems.
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 864 - 864
Опубликована: Янв. 10, 2024
Fear extinction is a phenomenon that involves gradual reduction in conditioned fear responses through repeated exposure to fear-inducing cues. Functional brain connectivity assessments, such as functional magnetic resonance imaging (fMRI), provide valuable insights into how regions communicate during these processes. Stress, ubiquitous aspect of life, influences learning and by changing the activity amygdala, prefrontal cortex, hippocampus, leading enhanced and/or impaired extinction. Glucocorticoid receptors (GRs) are key stress response show dual function regulation: while they enhance consolidation memories, also facilitate Accordingly, GR dysregulation associated with anxiety mood disorders. Recent advancements cognitive neuroscience underscore need for comprehensive understanding integrates perspectives from molecular, cellular, systems levels. In particular, neuropharmacology provides neurotransmitter receptor systems, aiding investigation mechanisms underlying regulation potential therapeutic targets. A notable player this context cortisol, hormone, which significantly both memory reconsolidation Gaining thorough intricate interactions has implications terms addressing psychiatric disorders related stress. This review sheds light on complex between processes, emotions, their neural bases. endeavor, our aim reshape comprehension fear, stress, emotional well-being, ultimately development interventions.
Язык: Английский
Процитировано
36
Biomedicines, Год журнала: 2024, Номер 12(3), С. 574 - 574
Опубликована: Март 5, 2024
Neurodegeneration poses a significant challenge for the fields of neuroscience and medicine, as it is underlying cause development advancement numerous neurodegenerative psychiatric disorders [...]
Язык: Английский
Процитировано
25
Biomedicines, Год журнала: 2024, Номер 12(3), С. 613 - 613
Опубликована: Март 8, 2024
Neuroscience, neurology, and psychiatry are rapidly evolving fields that aim to understand the complex mechanisms underlying brain function dysfunction, as well develop effective interventions for various neurological psychiatric disorders [...]
Язык: Английский
Процитировано
19
Cells, Год журнала: 2024, Номер 13(10), С. 790 - 790
Опубликована: Май 7, 2024
Translational research in neurological and psychiatric diseases is a rapidly advancing field that promises to redefine our approach these complex conditions [...]
Язык: Английский
Процитировано
19
Опубликована: Апрель 17, 2024
The editorial explores the realm of emerging translational research in neurology and psychiatry, providing insights into various subjects, including neurodegenerative disorders innovative therapeutic methods. main objective is to study neurological psychiatric disorders, such as Alzheimer's disease, with a particular emphasis on techniques for neural regeneration repair. highlights importance taking comprehensive approach studying treating complex conditions. This involves thoroughly reviewing papers causes, development, biomarkers, treatment options these emphasizes necessity using multidisciplinary integrative methods gain deeper understanding improve development an animal model recurrent primary dysmenorrhea showcases employed investigation gynecological illustrating capacity connect fundamental scientific knowledge practical medical applications. cooperative endeavors researchers clinicians emphasized this lay foundation revolutionary advancements that hold potential enhance outcomes individuals afflicted globally.
Язык: Английский
Процитировано
17
Biomedicines, Год журнала: 2024, Номер 12(5), С. 1083 - 1083
Опубликована: Май 13, 2024
Welcome to
Язык: Английский
Процитировано
17
Cells, Год журнала: 2023, Номер 12(22), С. 2649 - 2649
Опубликована: Ноя. 17, 2023
Migraine is a neurovascular disorder that can be debilitating for individuals and society. Current research focuses on finding effective analgesics management strategies migraines by targeting specific receptors neuropeptides. Nonetheless, newly approved calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) have 50% responder rate ranging from 27 to 71.0%, whereas CGRP receptor inhibitors 56 71%. To address the need novel therapeutic targets, researchers are exploring potential of another secretin family peptide, pituitary adenylate cyclase-activating polypeptide (PACAP), as ground-breaking treatment avenue migraine. Preclinical models revealed how PACAP affects trigeminal system, which implicated in headache disorders. Clinical studies demonstrated significance migraine pathophysiology; however, few clinical trials remain inconclusive: 1 mAb, AMG 301 showed no benefit prevention, while ligand Lu AG09222 significantly reduced number monthly days over placebo phase 2 trial. Meanwhile, vasoactive intestinal (VIP) gaining interest new target. In light recent advances research, we emphasize promising target treatment, highlighting member antimigraine armamentarium, especially patients who do not respond or contraindicated anti-CGRP therapies. By updating our knowledge its unique contribution pathophysiology, pave way reinforcing other peptides, including VIP, option migraines.
Язык: Английский
Процитировано
40
Опубликована: Окт. 12, 2023
Revealing the underlying pathomechanisms of neurological and psychiatric disorders, searching for new biomarkers, developing novel therapeutics all require translational research. In vivo in vitro disease models have been instrumental casting light on complex polygenic, multifactorial, heterogeneous mechanisms. most recent years, advanced preclinical revealed intriguing interaction sex/gender aging with pathogenesis clinical manifestations diseases. However, despite these advancements, there is still a great deal work to be done fully comprehend mechanisms diseases develop treatments that can significantly improve lives those who suffer from them. The current challenge field disease-modifying, effective long-lasting debilitating conditions high burden disease.The first edition research topic ‘Emerging Translational Research Neurological Psychiatric Diseases: From Vitro Vivo Models’ reinforces playing critical role bridging gap between basic applications. Also, it provides platform researchers share their findings advancements this field. This collection gathers 25 papers offering insights into latest potential avenues treatments. These cover various topics, including development models, use methods, application qualitative quantitative methods.
Язык: Английский
Процитировано
25
Cells, Год журнала: 2024, Номер 13(13), С. 1098 - 1098
Опубликована: Июнь 25, 2024
Migraine is a debilitating neurological disorder characterized by recurring episodes of throbbing headaches that are frequently accompanied sensory disturbances, nausea, and sensitivity to light sound [...]
Язык: Английский
Процитировано
13
Опубликована: Фев. 20, 2024
The central nervous system (CNS) is the final frontier in drug delivery because of blood-brain barrier (BBB), which poses significant barriers to access most drugs their targets. Kynurenic acid (KYNA), a tryptophan (Trp) metabolite, plays an important role behavioral functions and abnormal KYNA levels have been observed neuropsychiatric conditions. current challenge lies delivering CNS owing its polar side chain. Recently, C-3 chain modified analogs shown cross BBB; however, it unclear whether they retain biological parent molecule. This study examined impact analogs, specifically SZR-72, SZR-104, newly developed SZRG-21, on behavior. were administered intracerebroventricularly (i.c.v.), effects motor domain compared with those KYNA. Specifically, open field (OF) rotarod (RR) tests employed assess activity skills. SZR-104 increased horizontal exploratory OF test at dose 0.04 μmol/4 μL, while SZR-72 decreased vertical doses 0.1 μL. In RR test, neither nor showed any differences skills either dose. Side modification affects affective performance behavior, as results show for first time. this study, we that alter emotional components such motor-associated curiosity emotions. Consequently, design necessitates development precise strategies traverse BBB paying close attention modifications
Язык: Английский
Процитировано
12