Опубликована: Ноя. 23, 2023
Epigenetic changes are in gene expression that do not involve alterations to the basic DNA sequence. These lead establishing a so-called epigenetic code dictates which and when genes activated, thus orchestrating regulation playing central role development, health, disease. The brain, being for most formed by cells undergo renewal process through life, is highly prone risk of leading neuronal death neurodegenerative disorders, mainly at late age. Here we review main modifications have been described with particular attention those related onset developmental anomalies or conditions and/or occurring old methylation several types histone (acetylation, methylation, phosphorylation, ubiquitination, sumoylation, lactylation, crotonylation) major players these processes. They directly indirectly involved neurodegeneration Alzheimer’s Parkinson’s Therefore, this briefly describes mechanisms brain maturation, aging some important factors dynamically regulating contributing such as oxidative stress, inflammation, mitochondrial dysfunction.
Язык: Английский