SARS‐COV‐2 ORF8 as a Modulator of Cytokine Induction: Evidence and Search for Molecular Mechanisms DOI Open Access
Marília Inês Móvio,

Giovana Carneiro,

Isabella Lopes Martines

и другие.

Опубликована: Ноя. 30, 2023

Severe cases of SARS-CoV-2 infection are characterized by an immune response that leads to the overproduction pro-inflammatory cytokines, resulting in damage lungs and other organs. This remarkable increase cytokines inflammatory molecules is primary caused viral proteins, particular ORF8, a unique accessory protein specific SARS-CoV-2. In addition its role cytokine induction, ORF8 attributed with various functions, including ability evade type I interferon responses. Despite evidence, mechanisms through which exerts these functions remains subject controversy. this mini review, we discuss multifaceted roles as modulator response, focusing on IL-6. We also data from our studies indicating augments production IL-6 induced Poly(I:C) human embryonic kidney (HEK)-293 monocyte-derived dendritic cells (mono-DCs).

Язык: Английский

SARS‐COV‐2 ORF8 as a Modulator of Cytokine Induction: Evidence and Search for Molecular Mechanisms DOI Open Access
Marília Inês Móvio,

Giovana Carneiro,

Isabella Lopes Martines

и другие.

Опубликована: Ноя. 30, 2023

Severe cases of SARS-CoV-2 infection are characterized by an immune response that leads to the overproduction pro-inflammatory cytokines, resulting in damage lungs and other organs. This remarkable increase cytokines inflammatory molecules is primary caused viral proteins, particular ORF8, a unique accessory protein specific SARS-CoV-2. In addition its role cytokine induction, ORF8 attributed with various functions, including ability evade type I interferon responses. Despite evidence, mechanisms through which exerts these functions remains subject controversy. this mini review, we discuss multifaceted roles as modulator response, focusing on IL-6. We also data from our studies indicating augments production IL-6 induced Poly(I:C) human embryonic kidney (HEK)-293 monocyte-derived dendritic cells (mono-DCs).

Язык: Английский

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