Опубликована: Дек. 6, 2023
One of the major obstacles confronting formulation a mechanistic understanding for Alzheimer’s disease (AD) is its immense complexity – that traverses full structural and phenomenological spectrum, including molecular, macromolecular, cellular, neurological behavioural processes. This reflected by equally complex diversity risk factors associated with AD. However, more than merely mirroring complexity, also provide fundamental insights into aetiology pathogenesis AD as neurodegenerative disorder since they are central to initiation subsequent propagation. Based on systematic literature assessment, this review has identified 30 then extended analysis further identify neuroinflammation unifying mechanism present in all factors. Although other mechanisms (e.g. vasculopathy) were multiple factors, dysfunction neuroimmune-neuroinflammation axis was uniquely Though nature neuroinflammatory involvement varied, activation microglia release pro-inflammatory cytokines common pathway shared observation provides evidence importance immunopathic aetiopathogenesis
Язык: Английский