Nanopore Data-Driven T2T Genome Assemblies of Colletotrichum lini Strains DOI Creative Commons
Elizaveta A. Sigova, Ekaterina M. Dvorianinova, Alexander A. Arkhipov

и другие.

Journal of Fungi, Год журнала: 2024, Номер 10(12), С. 874 - 874

Опубликована: Дек. 16, 2024

Colletotrichum lini is a pathogenic fungus that infects flax and causes significant yield losses. In this study, we assembled the genomes of four highly virulent C. strains using Oxford Nanopore Technologies (ONT, R10.4.1 flow cells) Illumina platforms. The performance two tools developed for telomere-to-telomere (T2T) genome assembly was compared: Verkko Hifiasm. Prior to assembly, ONT reads were corrected HERRO algorithm. generated assemblies high completeness but low contiguity, while Hifiasm allowed generation T2T assemblies. Despite significantly different coverage with data (25–100×), equal contiguity obtained: 53.6–54.7 Mb, ten core chromosomes, or three accessory chromosomes. A comparative analysis polishing showed at certain (≥35×), additional did not improve its accuracy, even data. An structures revealed similarity between Thus, our approach enabled assembling only from obtained cells may be promising other fungal genera. These will allow accurate identification strain-specific differences chromosome level aid in development effective strategies protect anthracnose.

Язык: Английский

Uncovering the Host Range–Lifestyle Relationship in the Endophytic and Anthracnose Pathogenic Genus Colletotrichum DOI Creative Commons

Jacy Newfeld,

Ren Ujimatsu, Kei Hiruma

и другие.

Microorganisms, Год журнала: 2025, Номер 13(2), С. 428 - 428

Опубликована: Фев. 16, 2025

Colletotrichum includes agriculturally and scientifically important pathogens that infect numerous plants. They can also adopt an endophytic lifestyle, refraining from causing disease and/or even promoting plant growth when inoculated on a non-susceptible host. In this manner, the host range of fungus shift, depending whether it exhibits or pathogenic lifestyles. Some fungi, such as tofieldiae, shift between pathogenicity endophytism within same environmental conditions. Here, we aim to disentangle relationship lifestyle in Colletotrichum. Specifically, demonstrate is dependent colonized many fungi. We discuss ways which species may act endophytically alternative hosts, how comparative genomics has uncovered candidate molecules (namely effectors, CAZymes, secondary metabolites) underlying fungal merits using fungi alongside research, facilitates use reverse genetics uncover molecular determinants lifestyle. particular, reference Arabidopsis thaliana-Colletotrichum tofieldiae study system model for elucidating dual roles plant-fungus interactions, both pathogenic, through integrative omics approaches genetics. This because C. contains closely related endophytes, making ideal identifying approach could identify key targets effective pathogen management agriculture. Lastly, propose occupies different than will enhance our understanding globally significant genus lay groundwork future research examining plant-associated

Язык: Английский

Процитировано

0

Comparative Genomic Analysis of <em>Colletotrichum lini </em>Strains with Different Virulence on Flax DOI Open Access
Ekaterina M. Dvorianinova, Elizaveta A. Sigova,

Timur D. Mollaev

и другие.

Опубликована: Дек. 13, 2023

Colletotrichum lini is a flax fungal pathogen, comprising differently virulent strains. In this work, we sequenced the genomes of three C. strains different virulence: high #390-1, medium #757, and low #771. We obtained more than 100× genome coverage with Oxford Nanopore Technologies reads 50× Illumina data. To construct high-quality genomes, several assembly strategies were tested. The final assemblies using Canu – Racon ×2 Medaka Polca scheme 54.0-55.3 Mb in length, contained 26-32 contigs, had an N50 &gt; 5 BUSCO completeness 96%. Comparative analysis constructed showed similarity between mitochondrial nuclear genomes. However, rearrangement event loss 0.9 contig revealed. candidate effectors predicted sets proteins received after annotation. sequences extend knowledge on genetic diversity species are basis for establishing molecular mechanisms pathogenicity pathogen effective control anthracnose.

Язык: Английский

Процитировано

5

Complete Annotated Genome Assembly of Flax Pathogen Colletotrichum lini DOI Creative Commons
Elizaveta A. Sigova, Ekaterina M. Dvorianinova, Tatiana A. Rozhmina

и другие.

Journal of Fungi, Год журнала: 2024, Номер 10(9), С. 605 - 605

Опубликована: Авг. 26, 2024

is a fungal pathogen of flax that can cause significant yield and quality losses. In this work, we obtained the first complete annotated genome assembly highly virulent

Язык: Английский

Процитировано

1

Comparative Genomic Analyses of Colletotrichum lindemuthianum Pathotypes with Different Virulence Levels and Lifestyles DOI Creative Commons

Ma. Irene Morelos-Martínez,

Horacio Cano-Camacho,

Karla Morelia Díaz-Tapia

и другие.

Journal of Fungi, Год журнала: 2024, Номер 10(9), С. 651 - 651

Опубликована: Сен. 13, 2024

is the most frequent pathogenic fungus of common bean

Язык: Английский

Процитировано

1

Nanopore Data-Driven T2T Genome Assemblies of Colletotrichum lini Strains DOI Creative Commons
Elizaveta A. Sigova, Ekaterina M. Dvorianinova, Alexander A. Arkhipov

и другие.

Journal of Fungi, Год журнала: 2024, Номер 10(12), С. 874 - 874

Опубликована: Дек. 16, 2024

Colletotrichum lini is a pathogenic fungus that infects flax and causes significant yield losses. In this study, we assembled the genomes of four highly virulent C. strains using Oxford Nanopore Technologies (ONT, R10.4.1 flow cells) Illumina platforms. The performance two tools developed for telomere-to-telomere (T2T) genome assembly was compared: Verkko Hifiasm. Prior to assembly, ONT reads were corrected HERRO algorithm. generated assemblies high completeness but low contiguity, while Hifiasm allowed generation T2T assemblies. Despite significantly different coverage with data (25–100×), equal contiguity obtained: 53.6–54.7 Mb, ten core chromosomes, or three accessory chromosomes. A comparative analysis polishing showed at certain (≥35×), additional did not improve its accuracy, even data. An structures revealed similarity between Thus, our approach enabled assembling only from obtained cells may be promising other fungal genera. These will allow accurate identification strain-specific differences chromosome level aid in development effective strategies protect anthracnose.

Язык: Английский

Процитировано

0