RNA N6-Methyladenosine Modification in DNA Damage Response and Cancer Radiotherapy DOI Open Access
Cui Wang,

Shibo Yao,

Tinghui Zhang

и другие.

Опубликована: Янв. 12, 2024

N6-methyladenosine (M6A) modification is the most abundant internal chemical on RNA molecules in eukaryotes and can affect mRNA metabolism regulate transcription, nuclear export, splicing, degradation, translation, ets, has a significant impact various aspects of physiology or pathobiology. Radiotherapy common measure tumor treatment, variety cellular intrinsic mechanisms responses cells to ionizing radiation (IR) effectiveness cancer radiotherapy. In this review, we summarize discuss recent advances about roles M6A methylation radiation-induced DNA damage response, outcomes Insights into biology may facilitate improvement therapeutic strategies for radiotherapy as well radioprotection normal tissues.

Язык: Английский

Identification of m6A methyltransferase-related WTAP and ZC3H13 predicts immune infiltrates in glioblastoma DOI Creative Commons
Liyun Gao, Jiaxin Gao,

Jiayin He

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 5, 2025

Glioblastoma (GBM) is a prevalent and highly fatal primary malignant brain tumor. N6-methyladenosine (m6A) modification plays critical role in the development of WTAP ZC3H13 have been identified across various species. Immune contexture, which includes tumor microenvironment (TME), significant cancer progression treatment. This study aimed to explore potential impact between on immunological characteristics GBM. We utilized data from TCGA-GBM, GEO CGGA datasets obtain platform probe data. Patients with GBM were stratified into two clusters based expression using consensus clustering approach. infiltration within was assessed ESTIMATE, CIBERSORT ssGSEA methodologies. Functional disparities determined through gene set enrichment analysis (GSEA). Tumor mutation burden (TMB) immune checkpoint inhibitors (ICIs) also analyzed. Co-expression network (WGCNA) used identify genes associated WTAP/ZC3H13 immunity. Validation performed datasets. Our revealed that cluster1 exhibited higher but lower compared cluster2. Cluster1 showed levels TMB WGCNA 15 closely scores, notably CTLA4, CD27, ICOS, LAG3. results suggested influence contexture GBM, providing new insights immunity

Язык: Английский

Процитировано

2

RNA N6-Methyladenosine Modification in DNA Damage Response and Cancer Radiotherapy DOI Open Access
Cui Wang,

Shibo Yao,

Tinghui Zhang

и другие.

Опубликована: Янв. 12, 2024

N6-methyladenosine (M6A) modification is the most abundant internal chemical on RNA molecules in eukaryotes and can affect mRNA metabolism regulate transcription, nuclear export, splicing, degradation, translation, ets, has a significant impact various aspects of physiology or pathobiology. Radiotherapy common measure tumor treatment, variety cellular intrinsic mechanisms responses cells to ionizing radiation (IR) effectiveness cancer radiotherapy. In this review, we summarize discuss recent advances about roles M6A methylation radiation-induced DNA damage response, outcomes Insights into biology may facilitate improvement therapeutic strategies for radiotherapy as well radioprotection normal tissues.

Язык: Английский

Процитировано

2