Transcranial Direct Current Stimulation (tDCS) Ameliorates Stress-Induced Sleep Disruption via Activating Infralimbic Cortex-Ventrolateral Preoptic Area Projections DOI Open Access
Yujie Su, Pei-Lu Yi, Fang‐Chia Chang

и другие.

Опубликована: Янв. 15, 2024

Transcranial direct current stimulation (tDCS) is acknowledged for its non-invasive modulation of neuronal activity in psychiatric disorders. However, application insomnia research yields varied outcomes depending on different tDCS types and patient conditions. Our primary objective to elucidate efficiency uncover the underlying mechanisms treatment. We hypothesized that anodal prefrontal cortex activates glutaminergic projections from infralimbic (IL) ventrolateral preoptic area (VLPO) promote sleep. After administering 0.06 mA electrical currents 8 minutes, our results indicate significant non-rapid eye movement (NREM) enhancement naïve mice within initial 3 hours post-stimulation, persisting up 16-24 hours. In group, enhanced NREM sleep bout numbers during acute stress response improved REM duration subsequent insomnia. Sleep quality, assessed through delta powers, remains unaffected. Interference IL-VLPO pathway, utilizing designer receptors exclusively activated by drugs (DREADDs) with cre-DIO system, partially blocked tDCS's improvement stress-induced This study elucidated activation pathway mediates effect These findings support understanding effects disturbances, providing valuable insights future clinical applications therapy.

Язык: Английский

Transcranial Direct Current Stimulation (tDCS) Ameliorates Stress-Induced Sleep Disruption via Activating Infralimbic Cortex-Ventrolateral Preoptic Area Projections DOI Open Access
Yujie Su, Pei-Lu Yi, Fang‐Chia Chang

и другие.

Опубликована: Янв. 15, 2024

Transcranial direct current stimulation (tDCS) is acknowledged for its non-invasive modulation of neuronal activity in psychiatric disorders. However, application insomnia research yields varied outcomes depending on different tDCS types and patient conditions. Our primary objective to elucidate efficiency uncover the underlying mechanisms treatment. We hypothesized that anodal prefrontal cortex activates glutaminergic projections from infralimbic (IL) ventrolateral preoptic area (VLPO) promote sleep. After administering 0.06 mA electrical currents 8 minutes, our results indicate significant non-rapid eye movement (NREM) enhancement naïve mice within initial 3 hours post-stimulation, persisting up 16-24 hours. In group, enhanced NREM sleep bout numbers during acute stress response improved REM duration subsequent insomnia. Sleep quality, assessed through delta powers, remains unaffected. Interference IL-VLPO pathway, utilizing designer receptors exclusively activated by drugs (DREADDs) with cre-DIO system, partially blocked tDCS's improvement stress-induced This study elucidated activation pathway mediates effect These findings support understanding effects disturbances, providing valuable insights future clinical applications therapy.

Язык: Английский

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