Temporal Considerations in Brain Metastases Radiation Therapy: The Intersection of Chronobiology and Patient Profiles

Опубликована: Янв. 24, 2024

Background: The circadian system, a vital temporal regulator influencing physiological processes, has implications for cancer development and treatment response. Our study assesses timing's impact on whole-brain radiotherapy outcomes in brain metastases personalized therapy insights. Aim: Evaluate influence radiation timing its correlation with clinical outcomes. Identify patient populations benefiting from interventions synchronizing rhythms, considering subgroup differences potential disparities related to social determinants of health (SDoH). Design: IRB-approved retrospective analysis 237 patients undergoing (2017–2021), receiving over 80% treatments the morning or afternoon. Survival analyses utilized Kaplan–Meier curves. Setting/Participants: Single-institution involving radiotherapy. Collected demographic, disease, socioeconomic parameters electronic medical records. Results: Morning (n=158) showed trend towards improved overall survival vs. afternoon (n=79), median 158 79 days (p=0.20, HR=0.84, CI95% 0.84–0.91). Subgroup benefits females (p=0.04) trends controlled primary disease (p=0.11) breast (p=0.08). SDoH-based observed, Black lower-income exhibiting diminished influence. Conclusions: Emphasizes chronobiological factors' relevance therapy. correlates survival, particularly specific subgroups. Identifies based SDoH, laying foundation rhythms enhanced efficacy.

Язык: Английский

Circadian rhythms in haematological malignancies: therapeutic potential and personalised interventions

EBioMedicine, Год журнала: 2024, Номер 110, С. 105451 - 105451

Опубликована: Ноя. 19, 2024

Язык: Английский