Опубликована: Янв. 30, 2024
“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via gut-brain-axis (GBA) elevates heart rate variability (HRV), a general measure of health and well-being. dysbiotic microbiome, low biodiversity butyrate producers, triggers altered tryptophan metabolism release proinflammatory cytokines, predominantly TNF-α, IL-6, IL-1β, that also characterize chronic inflammation, oxidative stress, multitude diseases, all exhibiting HRV. Gut dysbiosis upregulates IFN-γ with it IDO (indoleamine 2,3 dioxygenase). Tryptophan pivots from serotonin synthesis to kynurenine, increasing kynurenine ratio (KTR). An elevated KTR is positively linked neurodegenerative autoimmune negatively Elevated activity not only enzymatic but an intracellular signal transducer potentiated by TGF-β. This cytokine primary determinant TME. The triple play prebiotic (d-mannose), probiotic (bifidobacteria lactobacilli), postbiotic (butyrate) might improve intestinal barrier integrity, suppress inflammatory triad, balance TGF-β, depress KTR, elevate HRV, extend lifespan.
Язык: Английский