Cell Membrane-Coated Nanoparticles for Precision Medicine: A Comprehensive Review of Coating Techniques for Tissue-Specific Therapeutics
Опубликована: Фев. 2, 2024
Nanoencapsulation
has
emerged
as
a
recent
improvement
in
the
delivery
of
drugs,
offering
and
improving
stability
bioavailability,
allowing
for
controlled
targeted
substances
to
specific
cells
or
tissues.
However,
traditional
nanoparticle
faces
challenges
such
short
circulation
time
immune
recognition.
To
address
these
issues,
cell
membrane-coated
nanoparticles
have
been
proposed
promising
alternative.
The
production
involves
three
key
stages:
lysis
membrane
fragmentation,
isolation,
coating.
Typically,
membranes
are
fragmented
using
hypotonic
combination
with
homogenization
sonication.
Subsequent
fragments
isolated
through
multiple
centrifugation
steps.
coating
can
be
achieved
extrusion,
sonication,
both
methods.
This
analysis
shows
absence
universally
applicable
method
coating,
stages
exhibit
notable
differences
their
procedures.
Here
we
review
ongoing
developments
approaches
that
position
this
technology
alternative
effective
drug
many
other
therapeutic
applications.
Язык: Английский
Precision Nanomedicine with Bio-Inspired Nanosystems: Recent Trends and Challenges in Mesenchymal Stem Cells Membrane-Coated Bioengineered Nanocarriers in Targeted Nanotherapeutics
Journal of Xenobiotics,
Год журнала:
2024,
Номер
14(3), С. 827 - 872
Опубликована: Июнь 24, 2024
In
the
recent
past,
formulation
and
development
of
nanocarriers
has
been
elaborated
into
broader
fields
opened
various
avenues
in
their
preclinical
clinical
applications.
particular,
cellular
membrane-based
nanoformulations
have
formulated
to
surpass
surmount
limitations
restrictions
associated
with
naïve
or
free
forms
therapeutic
compounds
circumvent
physicochemical
immunological
barriers
including
but
not
limited
systemic
barriers,
microenvironmental
roadblocks,
other
subcellular
hinderances-which
are
quite
heterogeneous
throughout
diseases
patient
cohorts.
These
drug
delivery
overcome
through
mesenchymal
cells
precision
therapeutics,
where
these
interventions
led
significant
enhancements
efficacies.
However,
still
focuses
on
optimization
paradigms
a
one-size-fits-all
resolutions.
As
stem
cell
engineered
highly
diversified
fashions,
being
optimized
for
delivering
payloads
more
better
personalized
modes,
entering
arena
as
well
nanomedicine.
this
Review,
we
included
some
advanced
which
designed
utilized
both
non-personalized
applicability
can
be
employed
improvements
nanotherapeutics.
present
report,
authors
focused
aspects
advancements
nanoparticle
conceptions
several
roadblocks
It
suggested
that
well-informed
designing
will
lead
appreciable
efficacy
payload
approaches
also
enable
tailored
customized
designs
MSC-based
applications,
finally
amending
outcomes.
Язык: Английский
Biomimetic Nanoparticles for Basic Drug Delivery
Pharmaceutics,
Год журнала:
2024,
Номер
16(10), С. 1306 - 1306
Опубликована: Окт. 7, 2024
Biomimetic
nanoparticles
(BMNPs)
are
innovative
nanovehicles
that
replicate
the
properties
of
naturally
occurring
extracellular
vesicles,
facilitating
highly
efficient
drug
delivery
across
biological
barriers
to
target
organs
and
tissues
while
ensuring
maximal
biocompatibility
minimal-to-no
toxicity.
BMNPs
can
be
utilized
for
therapeutic
payloads
imparting
novel
other
nanotechnologies
based
on
organic
inorganic
materials.
The
application
specifically
modified
membranes
coating
has
potential
enhance
their
efficacy
biocompatibility,
presenting
a
promising
pathway
advancement
technologies.
This
manuscript
is
grounded
in
fundamentals
biomimetic
technologies,
offering
comprehensive
overview
analytical
perspective
preparation
functionalization
BMNPs,
which
include
cell
membrane-coated
(CMCNPs),
artificial
cell-derived
vesicles
(ACDVs),
fully
synthetic
(fSVs).
review
examines
both
"top-down"
"bottom-up"
approaches
nanoparticle
preparation,
with
particular
focus
techniques
such
as
membrane
coating,
cargo
loading,
microfluidic
fabrication.
Additionally,
it
addresses
technological
challenges
solutions
associated
large-scale
production
clinical
related
Язык: Английский
Cardiac Cell Membrane-Coated Nanoparticles as a Potential Targeted Delivery System for Cardiac Therapy
Biomimetics,
Год журнала:
2025,
Номер
10(3), С. 141 - 141
Опубликована: Фев. 25, 2025
Cardiomyopathies,
a
cause
of
heart
failure,
are
predominant
death
globally
and
may
lead
to
discernible
myocardial
abnormalities.
Several
therapeutic
agents
were
discovered,
developed,
investigated,
evaluated
save
patients’
lives
improve
their
quality
life.
The
effective
administration
drugs
improves
outcomes
while
reducing
side
effects.
Nanoparticles
(NPs)
have
been
utilised
for
the
delivery
demonstrate
promise
in
ischaemia/reperfusion
injury.
However,
significant
limitations
NPs
include
non-specific
targeting
immunogenicity.
To
cardiac
biocompatibility,
surface
modifications
using
cell
membrane
(cCM)
coating
on
hypothesised.
Here,
cCMs
isolated
from
human
ventricular
line
(AC16),
mesoporous
silica
nanoparticles
(MSNs)
synthesised
then
coated
with
cCMs.
membrane-coated
(cCMCMSNs)
did
not
significantly
alter
encapsulation
efficiency
or
release
profile
loaded
drug
(Rhodamine
B)
comparison
MSN.
Moreover,
cCMCMSNs
demonstrated
enhanced
distribution
RhB
specifically
cells,
compared
other
types,
without
causing
cytotoxicity.
evaluate
immune
escape,
exposed
activated
macrophages,
demonstrating
that
phagocytosed
lesser
extent
than
This
study
synthesis
membranes
as
nanomedicine
technologies
enhance
selective
potentially
offering
an
alternate
method
cardiovascular
diseases.
Язык: Английский
Temperature-Dependent Cytokine Neutralization Induced by Magnetoelectric Nanoparticles: An In Silico Study
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13591 - 13591
Опубликована: Дек. 19, 2024
Inflammatory
cytokines
cooperate
to
maintain
normal
immune
homeostasis,
performing
both
a
protective
and
pro-inflammatory
action
in
different
body
districts.
However,
their
excessive
persistence
or
deregulated
expression
may
degenerate
into
tissue
chronic
inflammatory
status.
Advanced
therapies
should
be
designed
deploy
selective
cytokine
neutralizers
the
affected
tissues.
Magnetoelectric
nanoparticles
(MENPs)
possess
unexploited
potentialities,
conjugating
ferromagnetic
nature,
which
enables
confinement
specific
by
directed
positioning
when
subjected
low-intensity
magnetic
fields,
with
capability
generate
high
electric
fields
elevated
spatial
resolution
higher
fields.
This
work
proposes
exploit
extremely
localized
heat
generated
Joule’s
effect
around
MENPs
under
an
external
field
denature
harmful
hypothetical
site.
An
interdisciplinary
multiphysics
silico
study
was
conducted
provide
comprehensive
modeling
of
temperature
distribution
decorated
membrane-derived
microvesicle
(MV)
coating
allocate
antibody
bind
target
cytokine.
A
damage
model
also
implemented
estimation
influence
several
design
parameters
on
denaturation
efficacy,
final
goal
guiding
future
development
effective
MENPs-based
therapeutic
applications
strategies.
Язык: Английский