Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases DOI Open Access
Md. Niaj Morshed, Reshmi Akter, Imran Mahmud

и другие.

Опубликована: Фев. 2, 2024

Rare ginsenoside compound K (CK), is an intestinal microbial metabolite with a low natural abundance that primarily produced by physicochemical processing, side chain modification, or metabolic transformation in the gut. Moreover, CK exhibits potent biological activity compared to primary ginsenosides, which has raised concerns field of ginseng research and development as well ginsenosides-related dietary supplements products. Ginsenosides Rb1, Rb2, Rc are generally used substrate generate via several bio-conversion processes. Current shows wide range pharmacological actions including boosting osteogenesis, lipid glucose metabolism, oxidation, insulin resistance, anti-inflammatory, anti-apoptosis properties. Further on bioavailability toxicology can advance its medicinal application. The purpose this review lay groundwork for future clinical studies therapy disorders. Furthermore, pharmacology investigated review. findings indicate modulates signal-ing pathways associated AMPK, SIRT1, PPARs, WNTs, NF-kB. It also demonstrates positive therapeutic effect nonalcoholic fatty liver disease, obesity, hyperlipidemia, diabetes, complications, osteoporosis. Additionally, analogues showed more bioavailability, less toxicity, efficacy against disease states. Enhancing regulating hazardous variables crucial use trials.

Язык: Английский

Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases DOI Open Access
Md. Niaj Morshed, Reshmi Akter, Imran Mahmud

и другие.

Опубликована: Фев. 2, 2024

Rare ginsenoside compound K (CK), is an intestinal microbial metabolite with a low natural abundance that primarily produced by physicochemical processing, side chain modification, or metabolic transformation in the gut. Moreover, CK exhibits potent biological activity compared to primary ginsenosides, which has raised concerns field of ginseng research and development as well ginsenosides-related dietary supplements products. Ginsenosides Rb1, Rb2, Rc are generally used substrate generate via several bio-conversion processes. Current shows wide range pharmacological actions including boosting osteogenesis, lipid glucose metabolism, oxidation, insulin resistance, anti-inflammatory, anti-apoptosis properties. Further on bioavailability toxicology can advance its medicinal application. The purpose this review lay groundwork for future clinical studies therapy disorders. Furthermore, pharmacology investigated review. findings indicate modulates signal-ing pathways associated AMPK, SIRT1, PPARs, WNTs, NF-kB. It also demonstrates positive therapeutic effect nonalcoholic fatty liver disease, obesity, hyperlipidemia, diabetes, complications, osteoporosis. Additionally, analogues showed more bioavailability, less toxicity, efficacy against disease states. Enhancing regulating hazardous variables crucial use trials.

Язык: Английский

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