The Retinal Pigment Epithelium Pigment Granules: Norm, Age-related and Pathology DOI Open Access
А. Е. Донцов, М. А. Оstrovsky

Опубликована: Март 6, 2024

The retinal pigment epithelium (RPE), which ensures the normal functioning of neural retina, is a pigmented single-cell layer that separates retina from Bruch's membrane and choroid. There are three main types granules in RPE cells human eye: lipofuscin (LG) containing fluorescent “age pigment” lipofuscin, melanoprotein (melanosomes, melanolysosomes) screening melanin complex melanolipofuscin (MLG) simultaneously both pigments - lipofuscin. This review examines functional role aging process development oxidative stress associated pathologies cells. focus on light-induced degradation caused by reactive oxygen species. reasons leading to increased as result considered. A mechanism has been proposed explain phenomenon age-related decline content essence when part granule exposed light, species formed, destroy its part. As more formed with age degenerative diseases, epithelial ultimately disappears.

Язык: Английский

Retinal Pigment Epithelium Under Oxidative Stress: Chaperoning Autophagy and Beyond DOI Open Access
Yu. V. Markitantova, V. N. Simirskii

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1193 - 1193

Опубликована: Янв. 30, 2025

The structural and functional integrity of the retinal pigment epithelium (RPE) plays a key role in normal functioning visual system. RPE cells are characterized by an efficient system photoreceptor outer segment phagocytosis, high metabolic activity, risk oxidative damage. dysfunction is common pathological feature various diseases. Dysregulation cell proteostasis redox homeostasis accompanied increased reactive oxygen species generation during impairment lysosomal mitochondrial failure, accumulation waste lipidic protein aggregates. They inducers can trigger specific pathways death. Autophagy serves as important mechanism endogenous defense system, controlling survival under conditions cellular responses stress through degradation intracellular components. Impairment autophagy process itself result In this review, we summarize classical types stress-induced with emphasis on mediated molecular chaperones. Heat shock proteins, which represent hubs connecting life supporting cells, play special these mechanisms. Regulation stress-counteracting essential strategy for protecting against damage when preventing degenerative disease progression.

Язык: Английский

Процитировано

2
The Retinal Pigment Epithelium Pigment Granules: Norm, Age-related and Pathology DOI Open Access
А. Е. Донцов, М. А. Оstrovsky

Опубликована: Март 6, 2024

The retinal pigment epithelium (RPE), which ensures the normal functioning of neural retina, is a pigmented single-cell layer that separates retina from Bruch's membrane and choroid. There are three main types granules in RPE cells human eye: lipofuscin (LG) containing fluorescent “age pigment” lipofuscin, melanoprotein (melanosomes, melanolysosomes) screening melanin complex melanolipofuscin (MLG) simultaneously both pigments - lipofuscin. This review examines functional role aging process development oxidative stress associated pathologies cells. focus on light-induced degradation caused by reactive oxygen species. reasons leading to increased as result considered. A mechanism has been proposed explain phenomenon age-related decline content essence when part granule exposed light, species formed, destroy its part. As more formed with age degenerative diseases, epithelial ultimately disappears.

Язык: Английский

Процитировано

2