Trends and Pitfalls in the Progress of Network Pharmacology Research on Natural Products
Pharmaceuticals,
Год журнала:
2025,
Номер
18(4), С. 538 - 538
Опубликована: Апрель 7, 2025
Herbs,
used
as
food
and
a
source
of
medicine
for
centuries,
have
been
extensively
studied
over
time
their
chemical
pharmacological
properties,
with
two
main
aims
[...]
Язык: Английский
Adaptogens in Long-Lasting Brain Fatigue: An Insight from Systems Biology and Network Pharmacology
Pharmaceuticals,
Год журнала:
2025,
Номер
18(2), С. 261 - 261
Опубликована: Фев. 15, 2025
Long-lasting
brain
fatigue
is
a
consequence
of
stroke
or
traumatic
injury
associated
with
emotional,
psychological,
and
physical
overload,
distress
in
hypertension,
atherosclerosis,
viral
infection,
aging-related
chronic
low-grade
inflammatory
disorders.
The
pathogenesis
linked
to
disrupted
neurotransmission,
the
glutamate-glutamine
cycle
imbalance,
glucose
metabolism,
ATP
energy
supply,
which
are
multiple
molecular
targets
signaling
pathways
neuroendocrine-immune
blood
circulation
systems.
Regeneration
damaged
tissue
long-lasting
multistage
process,
including
spontaneously
regulating
hypothalamus-pituitary
(HPA)
axis-controlled
anabolic-catabolic
homeostasis
recover
harmonized
sympathoadrenal
system
(SAS)-mediated
function,
deregulated
gene
expression
rehabilitation.
driving
mechanism
spontaneous
recovery
regeneration
cross-talk
mediators
neuronal,
microglia,
immunocompetent,
endothelial
cells
collectively
involved
neurogenesis
angiogenesis,
plant
adaptogens
can
target.
Adaptogens
small
molecules
origin
that
increase
adaptability
organisms
stress
by
interaction
HPA
axis
SAS
(neuroendocrine-immune
cardiovascular
complex),
targeting
adaptive
GPCR
pathways.
Two
major
groups
comprise
(i)
phenolic
phenethyl
phenylpropanoid
derivatives
(ii)
tetracyclic
pentacyclic
glycosides,
whose
chemical
structure
be
distinguished
as
related
correspondingly
monoamine
neurotransmitters
(epinephrine,
norepinephrine,
dopamine)
steroid
hormones
(cortisol,
testosterone,
estradiol).
In
this
narrative
review,
we
discuss
multitarget
integrated
pharmacological
activity
botanical
ischemic
stroke,
fatigue;
time-dependent
dual
response
physiological
regulatory
systems
support
overload;
(iii)
dose-dependent
reversal
(hormetic)
effect
adaptogens.
This
review
shows
adaptogenic
concept
cannot
reduced
rectified
various
effects
on
selected
specific
modes
action
without
estimating
their
interactions
within
networks
complex
that,
turn,
regulates
other
(cardiovascular,
gastrointestinal,
reproductive
systems)
due
numerous
intra-
extracellular
communications
feedback
regulations.
These
result
polyvalent
pleiotropic
adaptogens,
essential
for
characterizing
distinct
types
botanicals.
They
trigger
defense
leads
extension
limits
resilience
inducing
mental
For
first
time,
justifies
potential
particularly
hybrid
preparation
(BHP)
Arctic
Root
Ashwagandha,
providing
rationale
use
individuals
experiencing
fatigue.
provided
insight
into
future
research
network
pharmacology
preventing
rehabilitating
following
trauma,
infections.
Язык: Английский
Pain Relief, Functional Recovery, and Chondroprotective Effects of Angelica gigas Nakai in Osteoarthritis Due to Its Anti-Inflammatory Property: An In Vitro and In Vivo Study
Nutrients,
Год журнала:
2024,
Номер
16(15), С. 2435 - 2435
Опубликована: Июль 26, 2024
Osteoarthritis
(OA),
characterized
by
chronic
pain
and
joint
degradation,
is
a
progressive
disease
primarily
induced
age-related
systemic
inflammation.
Язык: Английский
Efficacy and Safety of Orally Administered East Asian Herbal Medicine Combined with Narrowband Ultraviolet B against Psoriasis: A Bayesian Network Meta-Analysis and Network Analysis
Nutrients,
Год журнала:
2024,
Номер
16(16), С. 2690 - 2690
Опубликована: Авг. 13, 2024
Psoriasis
is
a
chronic,
immune-mediated
inflammatory
skin
disease
with
many
complications
and
poor
prognosis
that
imposes
significant
burden
on
individuals
society.
Narrowband
ultraviolet
B
(NB-UVB)
represents
cost-effective
non-drug
therapeutic
intervention
for
psoriasis.
East
Asian
herbal
medicine
(EAHM)
currently
being
investigated
its
potential
as
safe
effective
psoriasis
treatment.
Consequently,
it
has
the
to
be
employed
combination
therapy
NB-UVB.
The
objective
was
ascertain
efficacy
safety
of
EAHM
NB-UVB
identify
important
drugs
further
research.
In
this
study,
randomized
controlled
trials
(RCTs)
were
retrieved
from
ten
databases
in
Korea,
China,
Japan.
All
statistical
analyses
conducted
using
R
software
version
4.3.0.
primary
outcomes
Area
Severity
Index
(PASI)
incidence
rate
adverse
events
(AEs),
while
secondary
hematologic
markers
Dermatology
Life
Quality
(DLQI),
which
reflect
pathology
analysis
40
RCTs,
including
3521
participants,
demonstrated
exhibited
statistically
superiority
over
monotherapy
respect
outcomes.
Bayesian
network
meta-analysis
revealed
Investigator
Presciption
3
Ziyin
Liangxue
Decoction
consistent
relative
advantage
each
PASI-based
metric.
estimated
influence
ranking
all
individual
herbs
according
PageRank
centrality.
findings
study
suggest
EAHMs
co-administered
may
provide
additional
safety-related
benefits
patients
However,
quality
evidence
still
low,
high-quality
are
needed
reach
more
definitive
conclusions.
Язык: Английский
Multi-Omics Analysis in Mouse Primary Cortical Neurons Reveals Complex Positive and Negative Biological Interactions Between Constituent Compounds of Centella asiatica
Pharmaceuticals,
Год журнала:
2024,
Номер
18(1), С. 19 - 19
Опубликована: Дек. 27, 2024
Background:
A
water
extract
of
the
Ayurvedic
plant
Centella
asiatica
(L.)
Urban,
family
Apiaceae
(CAW),
improves
cognitive
function
in
mouse
models
aging
and
Alzheimer’s
disease
affects
dendritic
arborization,
mitochondrial
activity,
oxidative
stress
primary
neurons.
Triterpenes
(TT)
caffeoylquinic
acids
(CQA)
are
constituents
associated
with
these
bioactivities
CAW,
although
little
is
known
about
how
interactions
between
compounds
contribute
to
plant’s
therapeutic
benefit.
Methods:
Mouse
cortical
neurons
were
treated
CAW
or
equivalent
concentrations
four
TT
combined,
eight
CQA
twelve
combined
(TTCQA).
Treatment
effects
on
cell
transcriptome
(18,491
genes)
metabolome
(192
metabolites)
relative
vehicle
control
evaluated
using
RNAseq
metabolomic
analyses,
respectively.
Results:
Extensive
differentially
expressed
genes
(DEGs)
seen
all
treatments,
as
well
evidence
compounds.
Notably,
many
DEGs
treatment
not
observed
TTCQA
condition,
possibly
suggesting
reduced
TT.
Moreover,
additional
gene
activity
compared
indicates
presence
that
further
modulate
interactions.
Weighted
Gene
Correlation
Network
Analysis
(WGCNA)
identified
4
co-expression
modules
altered
by
treatments
extracellular
matrix
organization,
fatty
acid
metabolism,
cellular
response
stimuli,
immune
function.
Compound
interaction
patterns
at
eigengene
level
modules.
Interestingly,
metabolomics
analysis,
saw
highest
number
changes
individual
metabolites
(20),
followed
(15),
then
(8),
finally
(3).
WGCNA
analysis
found
two
significant
eigenmetabolite
differences
for
possible
compound
this
level.
Conclusions:
Four
expression
metabolite
types
applied.
This
methodology
demonstrated
existence
both
negative
positive
TT,
CQA,
Язык: Английский