Опубликована: Март 26, 2024
Oncolytic virotherapy is a promising immunotherapy approach for cancer treatment, utilizing viruses to preferentially infect and eliminate cells while stimulating immune responses. In this review we synthesize current literature on the molecular circuits of sensing response oncolytic virotherapy; focusing viral DNA or RNA by infected cells, cytokine danger-associated signal neighboring subsequent downstream activation pathways. The sequential sense-and-response mechanisms involve triggering sensors activate transcription factors related genes breadth We describe how signals induced in tumor upon can trigger diverse signaling pathways, activating both antigen-presenting cell-based innate T adaptive Insights into these complex provide valuable knowledge enhancing strategies.
Язык: Английский