Diverse Genetic Conflicts Mediated by Molecular Mimicry and Computational Approaches to Detect Them
Опубликована: Март 28, 2024
In
genetic
conflicts,
driver
and
killer
elements
achieve
biased
survival,
replication,
or
transmission
over
sensitive
targeted
through
a
wide
range
of
molecular
mechanisms,
including
mimicry.
Driving
mechanisms
manifest
at
all
organismal
levels,
from
the
propagation
individual
genes,
as
demonstrated
by
transposable
elements,
to
genomes,
illustrated
viruses,
cell
lineages,
in
cancer.
Targeted
genomes
are
vulnerable
mimicry
conserved
motifs
they
use
for
their
own
signaling
regulation.
Mimicking
these
enables
selfish
element
control
core
target
processes,
can
occur
sequence,
structure,
functional
level.
Molecular
was
first
appreciated
an
important
phenomenon
more
than
twenty
years
ago.
Modern
genomics
technologies,
databases,
machine
learning
approaches
offer
tremendous
potential
study
distribution
across
conflicts
nature.
Here,
we
explore
theoretical
expectations
between
conflicting
trends
known
outline
how
new
examples
be
gleaned
population
genomic
datasets.
We
discuss
mimics
involving
short
sequence-based
gene
duplications
evolve
convergently
mutations.
Whereas,
processes
that
involve
divergent
domains
fully-folded
structures
among
horizontal
transfer.
These
largely
based
on
small
number
organisms
should
reevaluated
general,
phylogenetically
independent
framework.
Currently,
publicly
available
databases
mined
genotypes
driving
non-mendelian
inheritance
patterns,
epistatic
interactions,
convergent
protein
structures.
A
subset
may
mimics.
propose
detecting
conflict
Язык: Английский
A Structural Proteome Screen Identifies Protein Mimicry in Host-Microbe Systems
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 13, 2024
Summary
Host-microbe
systems
are
evolutionary
niches
that
produce
coevolved
biological
interactions
and
a
key
component
of
global
health.
However,
these
have
historically
been
difficult
field
research
due
to
their
experimental
intractability.
Impactful
advances
in
health
will
be
obtained
by
leveraging
silico
screens
identify
genes
involved
mediating
interspecific
interactions.
These
predictions
progress
our
understanding
lay
the
groundwork
for
future
vitro
vivo
experiments
bioengineering
projects.
A
driver
host-manipulation
intracellular
survival
utilized
host-associated
microbes
is
molecular
mimicry,
critical
mechanism
can
occur
at
any
level
from
DNA
protein
structures.
We
applied
structure
prediction
alignment
tools
explore
bacterial
structural
proteomes
examples
mimicry.
By
Legionella
pneumophila
proteome
its
many
known
mimics,
we
developed
validated
screen
virtually
host-microbe
system
uncover
signals
mimics
represent
candidate
proteins
mediate
host
microbial
proteomes.
successfully
this
other
with
demonstrated
effects
on
health,
Helicobacter
pylori
Wolbachia
,
identifying
mimic
candidates
each
proteome.
discuss
roles
may
play
important
-induced
phenotypes
show
Wobachia
infection
partially
rescue
loss
one
factors.
This
work
demonstrates
how
genome-wide
offers
an
opportunity
functionally
systems.
Язык: Английский