Proteomic Signatures of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19: A Narrative Review
Children,
Год журнала:
2024,
Номер
11(10), С. 1174 - 1174
Опубликована: Сен. 26, 2024
Multisystem
Inflammatory
Syndrome
in
Children
(MIS-C)
is
a
post-infectious
complication
of
COVID-19.
MIS-C
has
overlapping
features
with
other
pediatric
inflammatory
disorders
including
Kawasaki
Disease
(KD),
Macrophage
Activation
(MAS),
Toxic
Shock
and
sepsis.
The
exact
mechanisms
responsible
for
the
clinical
overlap
between
these
conditions
remain
unclear,
biomarkers
that
could
distinguish
from
its
mimics
are
lacking.
This
study
aimed
to
provide
an
overview
how
proteomic
methods,
like
Mass
Spectrometry
(MS)
affinity-based
proteomics,
can
offer
detailed
understanding
pathophysiology
aid
diagnosis
prognosis
MIS-C.
Язык: Английский
From Genomics to Metabolomics: Molecular Insights into Osteoporosis for Enhanced Diagnostic and Therapeutic Approaches
Biomedicines,
Год журнала:
2024,
Номер
12(10), С. 2389 - 2389
Опубликована: Окт. 18, 2024
Osteoporosis
(OP)
is
a
prevalent
skeletal
disorder
characterized
by
decreased
bone
mineral
density
(BMD)
and
increased
fracture
risk.
The
advancements
in
omics
technologies—genomics,
transcriptomics,
proteomics,
metabolomics—have
provided
significant
insights
into
the
molecular
mechanisms
driving
OP.
These
technologies
offer
critical
perspectives
on
genetic
predispositions,
gene
expression
regulation,
protein
signatures,
metabolic
alterations,
enabling
identification
of
novel
biomarkers
for
diagnosis
therapeutic
targets.
This
review
underscores
potential
these
multi-omics
approaches
to
bridge
gap
between
basic
research
clinical
applications,
paving
way
precision
medicine
OP
management.
By
integrating
technologies,
researchers
can
contribute
improved
diagnostics,
preventative
strategies,
treatments
patients
suffering
from
related
conditions.
Язык: Английский
The Association of Systemic and Mandibular Bone Mineral Density in Postmenopausal Females with Osteoporosis
Medicina,
Год журнала:
2024,
Номер
60(8), С. 1313 - 1313
Опубликована: Авг. 14, 2024
Background/Objectives:
Osteoporosis
is
a
common
general
disease
that
mostly
affects
the
skeletal
system,
including
jawbone.
There
link
between
systemic
and
mandibular
osteoporosis.
This
study
aimed
at
assessing
association
(lumbar
spine
L1–L4,
femoral
neck,
total
hip)
bone
mineral
density
(BMD)
mandible
BMD
sites
in
Romanian
postmenopausal
females.
Methods:
A
of
97
menopausal
patients
were
studied,
62
with
osteoporosis
35
females
no
For
each
patient,
dual-energy
X-ray
absorptiometry
(DXA)
assessments
mandible,
proximal
femur,
hip,
lumbar
(L1–L4)
performed.
Mandibular
measurements
performed
using
distal
forearm
software,
followed
by
manual
analysis
after
contour
was
defined
case.
Results:
Comparing
control
groups,
there
significant
differences
examined
location.
The
(1.125
±
0.181506
g/cm2)
group
considerably
smaller
than
(1.35497
0.244397
g/cm2).
Correlations
different
significant:
neck
(r
=
0.738,
p
<
0.0001),
hip
0.735,
0.506,
0.891,
0.482,
0.466,
0.0001).
Conclusions:
correlations
spine,
BMD,
suggesting
density.
locations
may
help
predict
probability
Язык: Английский