Naturally Occurring Nor-Steroids and Their Design and Pharmaceutical Application
Опубликована: Апрель 16, 2024
The
main
focus
of
this
review
is
to
introduce
readers
the
fascinating
class
lipid
molecules
known
as
norsteroids,
exploring
their
distribution
across
various
biotopes
and
biological
activities.
provides
an
in-depth
analysis
modified
steroids,
including
A,
B,
C,
D-norsteroids,
each
characterized
by
distinct
structural
alterations.
These
modifications,
which
range
from
removal
specific
methyl
groups
changes
in
steroid
core,
result
unique
molecular
architectures
that
significantly
impact
activity
therapeutic
potential.
discussion
on
D-norsteroids
sheds
light
configurations
how
these
modifications
influence
pharmacological
properties.
also
presents
examples
natural
sources
produce
a
diverse
array
steroids
with
structures,
aforementioned
D-nor
variants.
compounds,
sourced
marine
organisms
like
sponges,
soft
corals
starfish,
well
terrestrial
entities
such
plants,
fungi,
bacteria.
exploration
encompasses
biosynthesis,
ecological
significance,
potential
medical
applications,
highlighting
crucial
area
interest
pharmacology
product
chemistry.
emphasizes
importance
researching
for
drug
development,
particularly
addressing
diseases
where
conventional
medications
are
inadequate
or
conditions
lacking
sufficient
options.
Examples
norsteroid
synthesis
provided
illustrate
practical
applications
research.
Язык: Английский
Chemical Diversity of Ketosteroids as Potential Therapeutic Agents
Microbiology Research,
Год журнала:
2024,
Номер
15(3), С. 1516 - 1575
Опубликована: Авг. 16, 2024
This
article
presents
a
comprehensive
overview
of
recent
discoveries
and
advancements
in
the
field
steroid
chemistry,
highlighting
isolation
characterization
various
steroidal
compounds
from
natural
sources.
paper
discusses
wide
range
steroids,
including
pregnane
alkaloids,
ketosteroids,
novel
triterpenoids,
derived
marine
organisms,
fungi,
plants.
Significant
findings
include
bioactive
such
as
cytotoxic
erectsterates
microorganisms,
soft
corals,
unusual
tetracyclic
penicillitone
fungal
culture,
innovative
derivatives
with
potential
anti-inflammatory
anticancer
activities.
The
synthesis
steroids
microorganisms
tool
for
pharmaceutical
development
is
also
explored,
showcasing
role
microbial
biotransformation
generating
drugs.
Additionally,
this
emphasizes
ecological
medicinal
relevance
these
compounds,
which
are
often
used
traditional
medicine
have
therapeutic
applications
treating
diseases
like
cancer
infections.
serves
vital
resource
researchers
interested
chemical
diversity
their
drug
discovery
development.
Язык: Английский