Bioengineering,
Год журнала:
2024,
Номер
11(12), С. 1250 - 1250
Опубликована: Дек. 10, 2024
Indirect
calorimetry
is
the
gold
standard
field-testing
technique
for
measuring
energy
expenditure
and
exercise
intensity
based
on
volume
of
oxygen
consumed
(VO
Sixteen
individuals
post
stroke
completed
treadmill
walking
exercises
with
concurrent
indirect
heart
rate
monitoring.
Using
70%
data,
forward
selection
regression
repeated
k-fold
cross-validation
was
used
to
build
wVO
Heart
rate-based
In
people
stroke,
Biomedicines,
Год журнала:
2025,
Номер
13(3), С. 736 - 736
Опубликована: Март 18, 2025
Background/Objectives:
Schizophrenia
(SZ)
is
a
complex
psychiatric
disorder
characterized
by
neurodegenerative
processes,
but
the
structural
brain
alterations
associated
with
its
progression
remain
poorly
understood.
This
study
investigated
changes
in
SZ,
particularly
fronto-temporal
and
limbic
regions,
explored
their
relationship
symptom
severity,
focus
on
mood-
emotion-related
symptoms.
Methods:
We
analyzed
MRI
data
from
74
SZ
patients
91
healthy
controls
(HCs)
using
voxel-based
morphometry
(VBM)
to
compare
whole-brain
grey
matter
volumes
(GMVs).
The
analysis
focused
correlations
between
GMV
severity
were
assessed
Positive
Negative
Syndrome
Scale
(PANSS)
Generalized
Psychopathology
(GP)
scale.
Results:
exhibited
significant
reductions
including
dorsolateral
prefrontal
cortex
(dlPFC)
temporal
pole,
compared
HCs.
Notably,
positive
association
was
found
right
inferior
gyrus
(ITG)
of
generalized
psychopathology,
as
well
anxiety,
depression,
mannerisms,
unusual
thought
content.
Further
post
hoc
identified
specific
cluster
mood-related
symptoms
contributing
GP
scale,
which
correlated
ITG.
Conclusions:
Our
findings
provide
new
evidence
suggesting
progressive
pattern.
role
ITG
requires
further
exploration,
it
could
offer
insights
into
pathophysiology
aid
distinguishing
other
disorders.
Biomedicines,
Год журнала:
2025,
Номер
13(5), С. 1045 - 1045
Опубликована: Апрель 25, 2025
Neurodegenerative
diseases
represent
a
daunting
global
challenge,
affecting
millions
worldwide
and
imposing
significant
clinical
socioeconomic
burdens
[...]
Biomedicines,
Год журнала:
2024,
Номер
12(8), С. 1706 - 1706
Опубликована: Авг. 1, 2024
This
study
explored
the
link
between
different
types
of
glaucoma
and
cognitive
function
in
a
cohort
620
Japanese
patients.
Participants
were
categorized
into
primary
open-angle
(PG),
exfoliation
(EG),
non-glaucomatous
control
groups.
The
findings
revealed
significant
decline
as
indicated
by
Mini-Cog
test
EG
group
(mean
±
SD:
4.0
1,
95%
CI:
3.9
to
4.2)
compared
PG
(4.4
0.1,
4.3
4.5,
Biomedicines,
Год журнала:
2024,
Номер
12(8), С. 1734 - 1734
Опубликована: Авг. 2, 2024
The
study
aimed
to
evaluate
the
efficacy
of
percutaneous
dilatational
tracheostomy
(PDT)
combined
with
adjuvant
therapies
in
preserving
vocal
function
amyotrophic
lateral
sclerosis
(ALS)
patients.
Biomedicines,
Год журнала:
2024,
Номер
12(8), С. 1898 - 1898
Опубликована: Авг. 20, 2024
Idiopathic
normal-pressure
hydrocephalus
(iNPH)
is
a
clinic-radiological
neurological
syndrome
presenting
with
cognitive
deficits,
gait
disturbances
and
urinary
incontinence.
It
often
coexists
Alzheimer's
disease
(AD).
Due
to
the
reversible
nature
of
iNPH
when
promptly
treated,
lot
studies
have
focused
on
possible
biomarkers,
among
which
are
cerebrospinal
fluid
(CSF)
biomarkers.
The
aim
present
study
was
determine
rate
beta-amyloid
pathology
AD
co-pathology
by
measuring
CSF
namely,
amyloid
beta
42
40
amino
acids
(Aβ42),
Aβ42/Aβ40
ratio,
total
Tau
protein
(t-Tau)
phosphorylated
at
threonine
181
(p-Tau),
in
cohort
patients,
as
well
investigate
associations
biomarkers
neuropsychological
profiles.
Fifty-three
patients
were
included
study.
Aβ42,
Aβ40,
t-Tau
p-Tau
measured
duplicate
double-sandwich
ELISA
assays.
evaluation
consisted
Mini-Mental
State
Examination,
Frontal
Assessment
Battery,
Five-Word
Test
CLOX
drawing
tests
1
2.
After
statistical
analysis,
we
found
that
rather
common
higher
values
levels,
existence
profile,
associated
more
severe
memory
impairment
patients.
In
conclusion,
our
has
confirmed
AD-co-pathology
markers
worse
decline
these
Biomedicines,
Год журнала:
2024,
Номер
12(11), С. 2568 - 2568
Опубликована: Ноя. 9, 2024
The
biosafety
of
gene
therapy
products
remains
a
major
challenge
to
their
introduction
into
the
clinic.
In
particular,
problem
immunogenicity
viral
vectors
is
focus
attention.
Large
animals
such
as
pigs,
whose
anatomical
and
physiological
characteristics
are
similar
those
humans,
have
an
advantage
in
testing
vector
systems.
Cells,
Год журнала:
2024,
Номер
13(22), С. 1910 - 1910
Опубликована: Ноя. 19, 2024
The
member
of
trace-amine
associated
receptor
family,
TAAR5
was
suggested
to
recognize
tertiary
amines,
mostly
in
the
olfactory
system;
however,
knocking
out
mice
showed
an
enhancing
effect
on
adult
neurogenesis
and
dopamine
neurotransmission
striatum.
To
estimate
role
TAAR5,
we
performed
gene
expression
profiling
striatal
samples
from
knockout
(KO)
their
wild-type
littermates.
higher
several
genes
involved
dopaminergic
signaling
downregulation
with
gliogenesis
were
revealed
TAAR5-KO
mice.
Meanwhile,
upregulating
synaptogenesis.
estimation
cell-type
relative
abundance
through
deconvolution
RNA
sequencing
data
demonstrated
that
striatum
contain
more
D2
receptor-expressing
medium
spiny
neurons
but
fewer
astrocytes
than
Our
findings
indicate
previously
identified
improvement
cognitive
functions
motor
coordination
may
activate
neurogenesis,
synaptogenesis,
synapse
organization
These
suggest
pharmaceutical
targeting
improve
striatum-dependent
or
functions.
At
same
time,
a
detailed
investigation
future
antagonists'
glia
development
is
necessary.
Bioengineering,
Год журнала:
2024,
Номер
11(12), С. 1250 - 1250
Опубликована: Дек. 10, 2024
Indirect
calorimetry
is
the
gold
standard
field-testing
technique
for
measuring
energy
expenditure
and
exercise
intensity
based
on
volume
of
oxygen
consumed
(VO
Sixteen
individuals
post
stroke
completed
treadmill
walking
exercises
with
concurrent
indirect
heart
rate
monitoring.
Using
70%
data,
forward
selection
regression
repeated
k-fold
cross-validation
was
used
to
build
wVO
Heart
rate-based
In
people
stroke,
