Are the Comorbidities Constitute an Intrinsic Factor for Long COVID? DOI Open Access
Rasha Ashmawy, Esraa Abdellatif Hammouda, Yousra A. El‐Maradny

и другие.

Опубликована: Май 2, 2024

Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID's burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.

Язык: Английский

Unraveling the role of the nucleocapsid protein in SARS-CoV-2 pathogenesis: From viral life cycle to vaccine development DOI
Yousra A. El‐Maradny,

Moustafa A. Badawy,

Kareem I. Mohamed

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 279, С. 135201 - 135201

Опубликована: Авг. 30, 2024

Язык: Английский

Процитировано

5
Optimizing Clinical Management of COVID-19: A Predictive Model for Unvaccinated Patients Admitted to ICU DOI Creative Commons

Ahmed Farhan,

Khouloud Ayed,

Sara Zayati

и другие.

Pathogens, Год журнала: 2025, Номер 14(3), С. 230 - 230

Опубликована: Фев. 27, 2025

This study investigates the impact of immunological and clinical factors on COVID-19 outcomes among unvaccinated individuals. A cohort 42 patients admitted to an intensive care unit was analyzed, focusing age, comorbidities, inflammatory cytokines (IL-6, TNF-α), anti-SARS-CoV-2 spike protein antibody levels (IgG) assess their influence hospital stay duration, recovery time, complications, mortality rates. The findings revealed that advanced cardiovascular disease, elevated pro-inflammatory significantly heightened risks severe complications mortality. Conversely, low IgG correlated with prolonged stays slower recovery. Multivariate analysis identified high IL-6 TNF-α as strong predictors adverse outcomes. research emphasizes need for early monitoring targeted management strategies mitigate COVID-19, especially high-risk populations.

Язык: Английский

Процитировано

0
Are the Comorbidities Constitute an Intrinsic Factor for Long COVID? DOI Open Access
Rasha Ashmawy, Esraa Abdellatif Hammouda, Yousra A. El‐Maradny

и другие.

Опубликована: Май 2, 2024

Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID's burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.

Язык: Английский

Процитировано

3