Опубликована: Май 6, 2024
Retention of placenta (RP) in crossbred cattle poses health, reproductive, and economic challenges linked to oxidative stress, hormonal imbalances, complex causative factors. Emphasizing the key role mitochondria phosphorylation (OXPHOS) hormone synthesis, our study is first explore differences OXPHOS activity, mitochondrial content, mtDNA-encoded gene expression between normal RP. In addition, gross morphological examination placental tissues from both groups revealed noticeable disparities cotyledons RP as compared placenta. Moreover, I specific activity was decreased RP, RT-qPCR analysis unveiled a significant reduction transcript levels 10 protein genes. While COX3 ATP8 genes showed no changes, ND6 increased Whereas, mtDNA copy number varied animals but statistically among groups. Retained manifests alterations various genes, potentially heightened energy demands or insufficiency, posing an elevated risk. Overall, suggests link abnormalities, expression, This connection could influence removal fetal membranes by affecting supply, balance, stress. also offers novel insights serves valuable animal model for studying insufficiency humans. Moving forward, comprehensive investigations are imperative unravel underlying mechanisms intricate roles context paving way targeted interventions mitigate cattle.
Язык: Английский