Опубликована: Май 7, 2024

A central hypothesis on brain functioning is that plasticity regulates the signals transfer function by modifying efficacy of synaptic transmission. In cerebellum, granular layer has been shown to control gain transmitted through mossy fiber pathway. Until now, impact incoming activity patterns was analyzed combining electrophysiological recordings in acute cerebellar slices and computational modeling, unraveling a broad spectrum different forms layer, often along with intrinsic excitability changes. Here, we attempt provide brief overview most prominent at excitatory synapses formed fibers onto principal neurons (granule cells, Golgi cells unipolar brush cells) layer. Specifically, will highlight current understanding mechanisms their functional implications plasticity, providing valuable insights into how inputs are processed reconfigured input stage.

Язык: Английский