Thyrotropin Releasing Hormone and Food-Intake in Mammals: An Update
Опубликована: Май 9, 2024
Thyrotropin
releasing
hormone
(TRH;
pGlu-His-Pro-NH2)
is
an
intercellular
signal
produced
mainly
by
neurons.
Among
the
multiple
pharmacological
effects
of
TRH,
that
on
food-intake
not
well
understood.
We
review
data
show
peripheral
injection
TRH
generally
produces
a
transient
anorexic
effect,
discuss
pathways
might
initiate
this
and
explain
its
short
half-life.
In
addition,
central
administration
can
produce
or
orexigenic
effects,
depending
site
injection,
are
likely
due
to
interaction
with
receptor
1.
Anorexic
most
notable
when
injected
into
hypothalamus
nucleus
accumbens,
while
effect
has
only
been
detected
brain
stem.
Functional
evidence
suggests
neurons
prime
candidate
vectors
for
action
include
caudal
raphe
nuclei
projecting
dorsal
motor
vagus,
possibly
from
tuberal
lateral
tuberomammillary
nuclei.
For
other
neurons,
anatomical
physiological
context
impact
in
each
synaptic
domain
still
poorly
The
manipulation
expression
well-defined
neuron
types
will
facilitate
discovery
role
control
scene.
Язык: Английский
Cell Type-Specific Expression of Purinergic P2X Receptors in the Hypothalamus
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(11), С. 5007 - 5007
Опубликована: Май 22, 2025
Purinergic
P2X
receptors
(P2X)
are
ATP-gated
ion
channels
that
broadly
expressed
in
the
brain,
particularly
hypothalamus.
As
ionic
with
high
permeability
to
calcium,
play
an
important
and
active
role
neural
functions.
The
hypothalamus
contains
a
number
of
small
nuclei
many
molecularly
defined
types
peptidergic
neurons
affect
wide
range
physiological
functions,
including
water
balance,
blood
pressure,
metabolism,
food
intake,
circadian
rhythm,
childbirth
breastfeeding,
growth,
stress,
body
temperature,
multiple
behaviors.
hypothalamic
neurons,
astrocytes,
tanycytes,
microvessels.
This
review
focuses
on
cell-type
specific
expression
most
nuclei,
such
as
supraoptic
nucleus
(SON),
paraventricular
(PVN),
suprachiasmatic
(SCN),
anteroventral
periventricular
(AVPV),
anterior
(AHN),
arcuate
(ARC),
ventromedial
(VMH),
dorsomedial
(DMH),
tuberomammillary
(TMN),
lateral
area
(LHA).>
also
notes
possible
extracellular
ATP
literature
summarized
here
shows
purinergic
signaling
is
involved
control
hypothalamic-pituitary
endocrine
system,
hypothalamic–neurohypophysial
systems
nonendocrine
Язык: Английский
Bilateral Correlational Behavior of Pyroglutamate Aminopeptidase I Activity in Rat Photoneuroendocrine Locations During a Standard 12:12 h Light–Dark Cycle
Symmetry,
Год журнала:
2024,
Номер
16(11), С. 1539 - 1539
Опубликована: Ноя. 17, 2024
We
previously
described
the
circadian
variation
and
bilateral
distribution
of
pyroglutamate
aminopeptidase
I
(pGluPI)
activity
levels
in
photoneuroendocrine
locations
adult
male
rats
during
a
standard
12:12
h
light–dark
cycle.
However,
correlational
analysis
between
such
has
not
yet
been
studied.
This
may
provide
new
data
about
unilateral
functional
interaction
under
light
dark
conditions.
analyzed
correlations
circuit
consisting
retina,
anterior
hypothalamus,
superior
cervical
ganglion,
pineal
gland,
as
well
other
related
locations:
posterior
pituitary,
occipital
cortex,
serum.
In
particular,
we
left
retina
or
right
versus
rest
locations,
sides
paired
structures
at
different
time
points
selected
from
12
periods.
Also,
profiles
results
were
compared
with
corresponding
mean
levels.
The
demonstrate
complexity
asymmetrical
brain
behavior.
correlation
profile
did
always
parallel
observed
values.
diurnal
behavior
differed
one
location
to
another.
Likewise,
them.
Particularly,
while
most
showed
positive
values,
that
hypothalamus
negative
value
13
period.
addition,
except
only
correlated
significantly
07
dynamic
asymmetry,
which
represents
challenge
for
understanding
its
meaning.
Язык: Английский