The Role of Vitamin D in the Management of Major Depressive Disorder: A Systematic Review
Pharmaceuticals,
Год журнала:
2025,
Номер
18(6), С. 792 - 792
Опубликована: Май 25, 2025
Background/Objective:
Depression
is
a
widespread
and
complex
disorder,
constituting
major
public
health
concern
due
to
its
significant
impact
on
mental
health.
Because
of
the
limitations
depressive
disorder
(MDD)
treatment,
recent
research
depression
management
has
focused
identifying
new
therapeutic
strategies.
The
effects
vitamin
D
brain,
mediated
through
various
mechanisms,
suggest
potential
implication
in
pathophysiology
depression.
In
this
systematic
review,
our
objective
was
evaluate
correlation
between
serum
levels
25-hydroxyvitamin
(25(OH)D)
based
evidence
from
cross-sectional
cohort
studies.
Furthermore,
we
also
assessed
effect
supplementation
relation
symptoms,
using
data
randomised
controlled
trials
(RCTs).
Methods:
To
achieve
proposed
objective,
have
compiled
report
that
includes
selection
empirical
necessary
review
relationship
regard,
relevant
articles
were
searched
platforms
such
as
PubMed,
MDPI,
ResearchGate,
Springer
Link,
Open,
ScienceDirect.
A
total
13,976
records,
published
2008
2024,
initially
identified
database
searches.
After
study
process,
performed
according
PRISMA
guidelines,
70
included
review.
Results:
According
most
studies,
results
highlight
an
inverse
25(OH)D
risk
depression,
well
severity
symptoms.
An
increase
concentration
associated
with
improvement
test
scores,
exerting
beneficial
both
incidence
prognosis
Conclusions:
Based
current
which
indicates
implications
neurobiological
mechanisms
obtained
demonstrate
could
represent
adjunctive
therapy
MDD.
More
rigorous
without
methodological
errors,
are
needed
correctly
definitively
assess
Язык: Английский
Low Vitamin D Concentration is Associated with Increased Depression Risk in Adults 20-44 Years-Old, an NHANES 2007-2018 Data Analysis with a Focus on Perinatal and Breastfeeding Status
Опубликована: Май 10, 2024
The
objective
was
to
investigate
associations
of
serum
vitamin
D
concentration
with
depressive
symptoms
and
assess
the
impact
has
on
occurrence
in
20–44-year-old
pregnant
mothers,
postpartum
women
(non-pregnant/postpartum
women),
men,
including
a
separate
subgroup
analysis
breastfeeding
non-breastfeeding
mothers.
study
populations
were
selected
from
2007-2018
NHANES
public
data.
Subjective
interview
data
laboratory
data,
symptoms,
concentration,
nutrient
intake,
demographic
information
utilized.
Two
diet
patterns
created
using
principal
component
Bayesian
multinomial
model
fit
predict
depression
outcomes
for
each
subpopulation.
estimates
log
slope
parameter
negative
all
cohorts;
as
increased,
probability
having
no
while
decreased.
cohort
had
steepest
slope,
followed
by
postpartum,
then
other
men.
Higher
more
decreasing
risk
mothers
compared
Among
higher
greater
influence
mothers'
than
Язык: Английский