Synthesis of Substituted 1,2-Dihydroisoquinolines by Palladium-Catalyzed Cascade Cyclization–Coupling of Trisubstituted Allenamides With Arylboronic Acids DOI Open Access
Masahiro Yoshida,

Ryunosuke Imaji,

Shinya Shiomi

и другие.

Опубликована: Июнь 7, 2024

1,2-Dihydroisoquinolines are important compounds due to their biological and medicinal activities, numerous approaches synthesis have been reported. In this study, a palladium-catalyzed cascade cyclization-coupling of trisubstituted allenamides containing bromoaryl moiety with arylboronic acids is described. The reaction proceeds via intramolecular cyclization, followed by transmetallation the acid resulting allylpalladium intermediate. A variety substituted 1,2-dihydroisoquinolines were concisely obtained using methodology because allenamides, as substrates, prepared from readily available propargylamines in one step.

Язык: Английский

Synthesis of Substituted 1,2-Dihydroisoquinolines by Palladium-Catalyzed Cascade Cyclization–Coupling of Trisubstituted Allenamides With Arylboronic Acids DOI Open Access
Masahiro Yoshida,

Ryunosuke Imaji,

Shinya Shiomi

и другие.

Опубликована: Июнь 7, 2024

1,2-Dihydroisoquinolines are important compounds due to their biological and medicinal activities, numerous approaches synthesis have been reported. In this study, a palladium-catalyzed cascade cyclization-coupling of trisubstituted allenamides containing bromoaryl moiety with arylboronic acids is described. The reaction proceeds via intramolecular cyclization, followed by transmetallation the acid resulting allylpalladium intermediate. A variety substituted 1,2-dihydroisoquinolines were concisely obtained using methodology because allenamides, as substrates, prepared from readily available propargylamines in one step.

Язык: Английский

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