Heavy Metals Interactions with Neuroglia and Gut Microbiota: Implications for Huntington’s Disease DOI Open Access
Yousef Tizabi, Samia Bennani,

Nacer El Kouhen

и другие.

Опубликована: Июнь 12, 2024

Huntington’s disease (HD) is a rare but progressive and devastating neurodegenerative characterized by involuntary movements, cognitive decline, executive dysfunction, neuropsychiatric conditions such as anxiety depression. It follows an autosomal dominant inheritance pattern. Thus, child who has parent with the mutated huntingtin (mHTT) gene 50% chance of developing disease. Since HTT protein involved in many critical cellular processes including neurogenesis, brain development, energy metabolism, transcriptional regulation, synaptic activity, vesicle trafficking, cell signaling, autophagy, its aberrant aggregates lead to disruption numerous pathways neurodegeneration. Essential heavy metals are vital at low concentrations, however, higher can exacerbate HD disrupting glial-neuronal communication, and/or causing dysbiosis (disturbance gut microbiota, GM), both which neuroinflammation further Here, we discuss detail interactions iron, manganese copper glial-neuron communication GM indicate how this knowledge may pave way for development new generation disease-modifying therapies HD.

Язык: Английский

Heavy Metals Interactions with Neuroglia and Gut Microbiota: Implications for Huntington’s Disease DOI Open Access
Yousef Tizabi, Samia Bennani,

Nacer El Kouhen

и другие.

Опубликована: Июнь 12, 2024

Huntington’s disease (HD) is a rare but progressive and devastating neurodegenerative characterized by involuntary movements, cognitive decline, executive dysfunction, neuropsychiatric conditions such as anxiety depression. It follows an autosomal dominant inheritance pattern. Thus, child who has parent with the mutated huntingtin (mHTT) gene 50% chance of developing disease. Since HTT protein involved in many critical cellular processes including neurogenesis, brain development, energy metabolism, transcriptional regulation, synaptic activity, vesicle trafficking, cell signaling, autophagy, its aberrant aggregates lead to disruption numerous pathways neurodegeneration. Essential heavy metals are vital at low concentrations, however, higher can exacerbate HD disrupting glial-neuronal communication, and/or causing dysbiosis (disturbance gut microbiota, GM), both which neuroinflammation further Here, we discuss detail interactions iron, manganese copper glial-neuron communication GM indicate how this knowledge may pave way for development new generation disease-modifying therapies HD.

Язык: Английский

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