Phytochemicals in Drug Discovery - A Confluence of Tradition and Innovation
Опубликована: Июнь 13, 2024
Phytochemicals
have
a
long
and
successful
history
in
drug
discovery.
With
recent
advancements
analytical
techniques
methodologies,
discovering
bioactive
leads
from
natural
compounds
has
become
easier.
Computational
like
molecular
docking,
QSAR
modelling
machine
learning,
network
pharmacology
are
among
the
most
promising
new
tools
that
allow
researchers
to
make
predictions
concerning
products'
potential
targets,
thereby
guiding
experimental
validation
efforts.
Additionally,
approaches
LC-MS
or
LC-NMR
speed
up
compound
identification
by
streamlining
processes.
Integrating
structural
computational
biology
aids
lead
identification,
thus
providing
invaluable
information
understand
how
phytochemicals
interact
with
targets
body.
Emerging
approach
is
learning
involving
deep
neural
networks
interrelate
phytochemical
properties
diverse
physiological
activities
such
as
antimicrobial
anticancer
effects.
Язык: Английский
Living Coral Displays, Research Laboratories, and Biobanks as Important Reservoirs of Chemodiversity with Potential for Biodiscovery
Marine Drugs,
Год журнала:
2025,
Номер
23(2), С. 89 - 89
Опубликована: Фев. 19, 2025
Over
the
last
decades,
bioprospecting
of
tropical
corals
has
revealed
numerous
bioactive
compounds
with
potential
for
biotechnological
applications.
However,
this
search
involves
sampling
in
natural
reefs,
and
is
currently
hampered
by
multiple
ethical
technological
constraints.
Living
coral
displays,
research
laboratories,
biobanks
offer
an
opportunity
to
continue
unravel
chemodiversity,
acting
as
"Noah's
Arks"
that
may
support
molecules
interest.
This
issue
even
more
relevant
if
one
considers
reefs
face
unprecedent
threats
irreversible
losses
impair
biodiscovery
new
products,
processes,
services.
displays
provide
controlled
environments
studying
producing
both
known
metabolites
under
varied
conditions,
they
are
not
prone
common
bottlenecks
associated
such
loss
source
replicability.
Research
laboratories
focus
on
a
particular
species
or
compound
using
were
cultured
ex
situ,
although
differ
from
wild
conspecifics
metabolite
production
quantitative
qualitative
terms.
Biobanks
collect
preserve
specimens,
tissues,
cells,
and/or
information
(e.g.,
genes,
microorganisms),
which
offers
plethora
data
study
compounds'
mode
action
without
having
cope
issues
related
access,
standardization,
regulatory
compliance.
Bioprospecting
these
settings
faces
several
challenges
opportunities.
On
hand,
it
difficult
ensure
complexity
highly
biodiverse
ecosystems
shape
chemodiversity
corals.
other
possible
maximize
biomass
fine
tune
synthesis
interest
environments.
Collaborative
efforts
needed
overcome
barriers
foster
opportunities
fully
harness
before
in-depth
knowledge
pool
irreversibly
lost
due
reefs'
degradation.
Язык: Английский
Neuroprotective insights into epigallocatechin gallate (EGCG) for neurodegenerative disorders
Exploration of neuroscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 24, 2025
Neurodegenerative
disorders,
including
Alzheimer’s,
Parkinson’s,
Huntington’s,
and
amyotrophic
lateral
sclerosis,
are
among
the
most
significant
health
concerns
worldwide,
characterized
by
neuronal
dysfunction,
oxidative
stress,
neuroinflammation,
protein
misfolding.
Epigallocatechin
gallate,
a
green
tea
polyphenol,
has
been
reported
to
possess
multifaceted
neuroprotective
properties.
It
reduces
stress
through
free
radical
scavenging,
activation
of
antioxidant
enzymes,
stabilization
mitochondrial
function.
also
inhibits
neuroinflammation
modulation
key
signaling
pathways.
suppresses
amyloid-beta
aggregation
in
Alzheimer’s
alpha-synuclein
fibrillation
thus
attenuating
toxic
accumulation.
Its
activity
induction
autophagy
promotion
synaptic
plasticity
supports
survival
However,
low
bioavailability
metabolic
instability
hinder
its
translation
into
clinic.
Strategies
nanoparticle
encapsulation,
structural
modifications,
combination
therapies
being
explored
overcome
these
challenges.
Future
research
could
establish
epigallocatechin
gallate
as
viable
candidate
for
managing
neurodegenerative
disorders.
Язык: Английский
Mandragora autumnalis Distribution, Phytochemical Characteristics, and Pharmacological Bioactivities
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 328 - 328
Опубликована: Фев. 26, 2025
In
the
Mediterranean
and
Himalayan
regions,
genus
Mandragora
(family
Solanaceae),
sometimes
called
mandrake,
is
widely
utilized
in
herbal
therapy
well-known
for
its
mythical
associations.
Objective:
To
compile
up-to-date
information
on
M.
autumnalis’s
therapeutic
properties.
Its
pharmacological
properties
phytochemical
composition
are
particularly
covered
managing
several
illnesses,
including
diabetes,
cancer,
heart
disease.
Methods:
Articles
review
topic
were
found
by
searching
major
scientific
literature
databases,
such
as
PubMed,
Scopus,
ScienceDirect,
SciFinder,
Chemical
Abstracts,
Medicinal
Aromatic
Plants
Abstracts.
Additionally,
general
online
searches
conducted
using
Google
Scholar
Google.
The
time
frame
search
included
items
released
from
1986
to
2023.
Results:Mandragora
has
been
shown
contain
a
variety
of
phytochemicals,
coumarins,
withanolides,
alkaloids.
characteristics
autumnalis,
increasing
macrophage
anti-inflammatory
activity,
free
radicals
inhibition,
bacterial
fungal
growth
cytotoxic
anticancer
activities
vivo
vitro
against
cancer
cell
lines,
enzyme-inhibitory
properties,
attributed
these
phytochemicals.
Furthermore,
autumnalis
also
inhibits
cholinesterase,
tyrosinase,
α-amylase,
α-glucosidase,
radicals.
On
other
hand,
metabolic
risk
factors,
inhibition
diabetes-causing
enzymes
obesity,
have
treated
dried
ripe
berries.
Conclusions:
Investigations
into
revealed
that
this
plant
rich
reservoir
new
bioactive
substances.
This
aims
provide
insight
botanical
ecological
summary
components
antioxidant,
antimicrobial,
antidiabetic,
anticancer,
well
toxicological
implications,
where
low
activity
normal
VERO
line
shown.
More
research
necessary
ensure
efficacy
safety.
Still,
it
understand
molecular
mechanism
action
behind
observed
effects
clarify
potential.
Язык: Английский
Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
47(1), С. 6 - 6
Опубликована: Дек. 26, 2024
Cancer
remains
a
significant
medical
challenge,
necessitating
the
discovery
of
novel
therapeutic
agents.
Ribosomally
synthesized
and
post-translationally
modified
peptides
(RiPPs)
from
plants
have
emerged
as
promising
source
anticancer
compounds,
offering
unique
structural
diversity
potent
biological
activity.
This
review
identifies
discusses
cytotoxic
RiPPs
across
various
plant
families,
focusing
on
their
absolute
chemical
structures
reported
activities
against
cancer
cell
lines.
Notably,
plant-derived
such
rubipodanin
A
mallotumides
A-C
demonstrated
low
nanomolar
IC50
values
multiple
types,
highlighting
potential.
By
integrating
traditional
ethnobotanical
knowledge
with
modern
genomic
bioinformatic
approaches,
this
study
underscores
importance
resource
for
developing
innovative
treatments.
These
findings
pave
way
further
exploration
RiPPs,
emphasizing
role
in
addressing
ongoing
challenges
oncology
enhancing
repertoire
effective
therapies.
Язык: Английский
Review of Cathepsin K Inhibitor Development and the Potential Role of Phytochemicals
Molecules,
Год журнала:
2024,
Номер
30(1), С. 91 - 91
Опубликована: Дек. 29, 2024
Cathepsin
K
plays
a
pivotal
role
in
bone
resorption
and
has
emerged
as
prominent
therapeutic
target
for
treating
bone-related
diseases
such
osteoporosis.
Despite
significant
advances
synthetic
inhibitor
development,
none
have
achieved
FDA
approval
due
to
safety
efficacy
challenges.
This
review
highlights
the
potential
of
phytochemicals
alternative
inhibitors,
emphasizing
their
natural
origin,
structural
diversity,
minimal
adverse
effects.
Key
phytochemicals,
including
AC-5-1,
Cycloaltilisin
6,
7,
Nicolaioidesin
C,
Panduratin
A,
were
examined
inhibitory
activities
against
cathepsin
K.
While
these
compounds
exhibit
varying
IC50
values,
docking
studies
revealed
interactions
within
K’s
active
site,
particularly
involving
critical
residues
Cys25
His162.
However,
challenges
lower
potency
compared
inhibitors
limited
vivo
underscore
need
optimization
comprehensive
preclinical
evaluations.
discusses
biological
insights,
current
limitations,
future
strategies
advancing
phytochemical-based
toward
clinical
applications
managing
K-associated
diseases.
Язык: Английский