Persistent Post-COVID-19 Olfactory Dysfunction and Its Association with Autonomic Nervous System Function: A Case–Control Study DOI Creative Commons

Lojine Ayoub,

Abeer F. Almarzouki, Rajaa Al‐Raddadi

и другие.

Diseases, Год журнала: 2024, Номер 13(1), С. 4 - 4

Опубликована: Дек. 28, 2024

Background: Following the Coronavirus Disease 2019 (COVID-19) pandemic, many patients have reported ongoing smell and taste issues. This study aims to investigate prevalence of olfactory gustatory dysfunction among with a history COVID-19 its association autonomic disability. Patient Methods: case–control included group (n = 82) control 82). Olfactory dysfunction, including parosmia problems, was explored using self-reports Quick Smell Identification Test (QSIT). The between post-COVID-19 disability severity alterations also analyzed. Moreover, function evaluated Composite Autonomic Symptom Scale-31 (COMPASS-31) assess dysfunction. Results: Significantly higher rates (26.8%) (14.6%) were for compared group. Post-COVID-19 36.6 times more issues 8.22 than controls. Parosmia scores significantly worse in group, while QSIT showed no significant difference groups. However, those exhibited No observed altered or taste. Higher secretomotor associated abnormal scores; other domains COMPASS-31 scale associations. Conclusions: findings indicated potential link Further studies are needed elucidate mechanisms underlying persistent patients.

Язык: Английский

Receptors Involved in COVID-19-Related Anosmia: An Update on the Pathophysiology and the Mechanistic Aspects DOI Open Access
Noor Nadhim Al-Saigh, Amani A. Harb, Shtaywy Abdalla

и другие.

Опубликована: Июнь 27, 2024

Background Olfactory perception is an important physiological function for the human well-being and health. Loss of olfaction, or anosmia, caused by viral infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) received a considerable attention especially in persistent cases that take long time to recover. Objectives This review discusses integration different components olfactory epithelium serve structural functional unit, explores how they are affected during infections, leading development dysfunction. Methods The mainly focused on role receptors mediating disruption signal transduction pathways ACE2, TMPRSS2 protease, neuropilin 1 (NRP1), basigin (CD147), olfactory, TRPV1, purinergic, interferon gamma receptors. Furthermore, compromised epithelial sodium channel (ENaC) induced SARS-CoV-2 infection its contribution dysfunction also discussed. Results Collectively, this provides fundamental information about many types may modulate olfaction participate It will help understand underlying pathophysiology virus-induced anosmia which finding designing effective therapies targeting molecules involved invasion olfaction. Conclusion wide complex spectrum mediates reflects ways can be therapeutically managed.

Язык: Английский

Процитировано

5
Polyunsaturated Fatty Acids as Potential Treatments for COVID-19-Induced Anosmia DOI Creative Commons
Yuhan Wang,

Chung-Wei Lin,

Chiung-Wei Huang

и другие.

Biomedicines, Год журнала: 2024, Номер 12(9), С. 2085 - 2085

Опубликована: Сен. 12, 2024

Some individuals with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) experience anosmia, or loss of smell. Although the prevalence anosmia has decreased emergence Omicron variant, it remains a significant concern. This review examines potential role polyunsaturated fatty acids (PUFAs), particularly omega-3 PUFAs, in treating COVID-19-induced by focusing on underlying mechanisms condition. Omega-3 PUFAs are known for their anti-inflammatory, neuroprotective, and neurotransmission-enhancing properties, which could potentially aid olfactory recovery. However, study findings inconsistent. For instance, placebo-controlled randomized clinical trial found no effect PUFA supplementation recovery patients anosmia. These mixed results highlight limitations existing research, including small sample sizes, lack placebo controls, short follow-up periods, combined treatments. Therefore, more rigorous, large-scale studies urgently needed to definitively assess therapeutic dysfunction. Further research is also crucial explore broader managing viral infections promoting sensory

Язык: Английский

Процитировано

0
Development of an rpS6-Based Ex Vivo Assay for the Analysis of Neuronal Activity in Mouse and Human Olfactory Systems DOI Open Access

Emma Broillet-Olivier,

Yvan Wenger,

Noah Gilliand

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 13173 - 13173

Опубликована: Дек. 7, 2024

Olfactory sensitivity to odorant molecules is a complex biological function influenced by both endogenous factors, such as genetic background and physiological state, exogenous environmental conditions. In animals, this vital ability mediated olfactory sensory neurons (OSNs), which are distributed across several specialized subsystems depending on the species. Using phosphorylation of ribosomal protein S6 (rpS6) in OSNs following stimulation, we developed an ex vivo assay allowing simultaneous conditioning stimulation different mouse subsystems, including main epithelium, vomeronasal organ, Grueneberg ganglion. This approach enabled us observe odorant-induced neuronal activity within demonstrate impact conditioning, temperature variations, sensitivity, specifically We further applied our rpS6-based human system demonstrated its feasibility. Our findings show that analyzing rpS6 signal intensity robust highly reproducible indicator various systems, while avoiding stress some experimental limitations associated with exposure. The potential extension other paradigms well application animal species, diagnostics, also discussed.

Язык: Английский

Процитировано

0
Ion Channels in Odor Information Processing of Neural Circuits of the Vertebrate Olfactory Bulb DOI Open Access

Yun-Qing Yu,

Ping Liao, Ruotian Jiang

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13259 - 13259

Опубликована: Дек. 10, 2024

Olfactory disorders and their associated complications present a considerable challenge to an individual's quality of life emotional wellbeing. The current range treatments, including surgical procedures, pharmacological interventions, behavioral training, frequently proves ineffective in restoring olfactory function. bulb (OB) is essential for odor processing plays pivotal role the development these disorders. Despite acknowledged significance ion channels sensory functions related pathologies, specific involvement OB remains unexplored. This review presents overview various channel families regulating neuronal excitability, synaptic transmission, complex processes perception. objective this was elucidate function, providing new insights into diagnosis treatment dysfunction.

Язык: Английский

Процитировано

0
Persistent Post-COVID-19 Olfactory Dysfunction and Its Association with Autonomic Nervous System Function: A Case–Control Study DOI Creative Commons

Lojine Ayoub,

Abeer F. Almarzouki, Rajaa Al‐Raddadi

и другие.

Diseases, Год журнала: 2024, Номер 13(1), С. 4 - 4

Опубликована: Дек. 28, 2024

Background: Following the Coronavirus Disease 2019 (COVID-19) pandemic, many patients have reported ongoing smell and taste issues. This study aims to investigate prevalence of olfactory gustatory dysfunction among with a history COVID-19 its association autonomic disability. Patient Methods: case–control included group (n = 82) control 82). Olfactory dysfunction, including parosmia problems, was explored using self-reports Quick Smell Identification Test (QSIT). The between post-COVID-19 disability severity alterations also analyzed. Moreover, function evaluated Composite Autonomic Symptom Scale-31 (COMPASS-31) assess dysfunction. Results: Significantly higher rates (26.8%) (14.6%) were for compared group. Post-COVID-19 36.6 times more issues 8.22 than controls. Parosmia scores significantly worse in group, while QSIT showed no significant difference groups. However, those exhibited No observed altered or taste. Higher secretomotor associated abnormal scores; other domains COMPASS-31 scale associations. Conclusions: findings indicated potential link Further studies are needed elucidate mechanisms underlying persistent patients.

Язык: Английский

Процитировано

0