Improved Biomineralization Using Cellulose Acetate/Magnetic Nanoparticles Composite Membranes
Polymers,
Год журнала:
2025,
Номер
17(2), С. 209 - 209
Опубликована: Янв. 15, 2025
Following
implantation,
infections,
inflammatory
reactions,
corrosion,
mismatches
in
the
elastic
modulus,
stress
shielding
and
excessive
wear
are
most
frequent
reasons
for
orthopedic
implant
failure.
Natural
polymer-based
coatings
showed
especially
good
results
achieving
better
cell
attachment,
growth
tissue-implant
integration,
it
was
found
that
inclusions
of
nanosized
fillers
coating
structure
improves
biomineralization
consequently
osseointegration,
as
nanoparticles
represent
calcium
phosphate
nucleation
centers
lead
to
deposition
highly
organized
hydroxyapatite
crystallites
on
surface.
In
this
study,
magnetic
synthesized
by
co-precipitation
method
were
used
preparation
cellulose
acetate
composite
through
phase-inversion
method.
The
ability
membranes
tested
Taguchi
method,
nanostructured
formed
at
surface
membrane
(with
a
higher
organization
degree
purity,
Ca/P
percentage
closer
one
seen
with
stoichiometric
hydroxyapatite,
compared
deposited
neat
acetate).
obtained
indicate
potential
new
application
field
orthopedics.
Язык: Английский
Evaluation of Superparamagnetic Fe3O4-Ag Decorated Nanoparticles: Cytotoxicity Studies in Human Fibroblasts (HFF-1) and Breast Cancer Cells (MCF-7)
Опубликована: Июль 1, 2024
This
study
investigates
the
cytotoxicity
profile
of
superparamagnetic
Fe3O4-Ag
decorated
nanoparticles
against
human
fibroblasts
(HFF-1)
and
breast
cancer
cells
(MCF-7).
The
underwent
comprehensive
characterization
employing
scanning
electron
microscopy
(SEM),
X-ray
diffraction
(XRD)
analysis,
photoelectron
spectroscopy
(XPS),
magnetic
assays
including
hysteresis
curves
zero-field-cooled
(ZFC)
plots.
Notably,
exhibited
behavior
as
evidenced
by
studies.
Remarkably,
demonstrated
that
both
HFF-1
MCF-7
maintained
nearly
100%
viability
upon
nanoparticle
exposure.
These
results
underscore
outstanding
biocompatibility
Fe3O4/Ag
nanoparticles,
suggesting
their
potential
utility
in
biomedical
applications
such
drug
delivery
targeting
without
inducing
significant
cytotoxic
effects.
investigation
advances
our
understanding
nanostructured
materials
biological
settings
highlights
promising
prospects
biomedicine.
Язык: Английский