Capsinoids Promotes an Increase in Enzyme Antioxidative Activity and Prevents the Injury Cardiac Induced by Obesity without Positively Modulate the Cardiac Oxidative Biomarkers DOI Open Access

Késsia Cristina Carvalho Santos,

Lucas Furtado Domingos,

Fabiane Merigueti Nunes

и другие.

Опубликована: Июль 24, 2024

Capsinoids (CAP) are potential antioxidant agents capable of reducing oxidative damage and the resulting complications triggered by obesity. Thus, aim this study was to investigate effects CAP on adiposity biomarkers cardiac stress in rats with obesity induced a high-fat diet. Male Wistar were exposed diet for 27 consecutive weeks. After characterization (week 19), some obese (Ob) animals began receive capsinoids (10 mg/kg/day) orogastric gavage. Adiposity comorbidities assessed. In heart, remodeling, injury determinated. The treatment did not reduce d obesity, but they efficient cholesterol levels. cause difference heart LV mass, despite having reduced troponin I concentrations. Furthermore, capisinoids increase advanced oxidation proteins products (AOPP) carbonylated (CBO) caused tissue. Besides that, it observed that ObCap presented high levels malondialdehyde greater activity enzymes compared Ob. conclusion, lead significant positive obesity-induced stress.

Язык: Английский

Capsinoids Promotes an Increase in Enzyme Antioxidative Activity and Prevents the Injury Cardiac Induced by Obesity without Positively Modulate the Cardiac Oxidative Biomarkers DOI Open Access

Késsia Cristina Carvalho Santos,

Lucas Furtado Domingos,

Fabiane Merigueti Nunes

и другие.

Опубликована: Июль 24, 2024

Capsinoids (CAP) are potential antioxidant agents capable of reducing oxidative damage and the resulting complications triggered by obesity. Thus, aim this study was to investigate effects CAP on adiposity biomarkers cardiac stress in rats with obesity induced a high-fat diet. Male Wistar were exposed diet for 27 consecutive weeks. After characterization (week 19), some obese (Ob) animals began receive capsinoids (10 mg/kg/day) orogastric gavage. Adiposity comorbidities assessed. In heart, remodeling, injury determinated. The treatment did not reduce d obesity, but they efficient cholesterol levels. cause difference heart LV mass, despite having reduced troponin I concentrations. Furthermore, capisinoids increase advanced oxidation proteins products (AOPP) carbonylated (CBO) caused tissue. Besides that, it observed that ObCap presented high levels malondialdehyde greater activity enzymes compared Ob. conclusion, lead significant positive obesity-induced stress.

Язык: Английский

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