Опубликована: Июль 25, 2024
Periodontal disease, a multifactorial inflammatory condition affecting the supporting structures of teeth, has been increasingly recognized for its association with various systemic diseases. Understanding molecular comorbidities periodontal disease is crucial elucidating shared pathogenic mechanisms and potential therapeutic targets. In this study, we conducted comprehensive literature biological database mining utilizing tools such as DisGeNET2R, Romin, Rentrez R libraries to identify diseases sharing associated genes, proteins, or pathways periodontitis. Our analysis revealed significant overlaps between several conditions, including cardiovascular diseases, diabetes mellitus, rheumatoid arthritis, bowel Shared implicated in pathogenesis these periodontitis encompassed dysregulation mediators, immune response pathways, oxidative stress alterations extracellular matrix. Furthermore, network unveiled key hub genes proteins that play pivotal roles crosstalk comorbidities, offering targets intervention. Insights gained from integrative approach shed light on intricate interplay health well-being, emphasizing importance interdisciplinary collaboration developing personalized treatment strategies patients comorbidities.
Язык: Английский