Опубликована: Июль 29, 2024
Research interest in the occurrence, distribution, fate, and toxicity of N-(1,3-Dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD) quinone, a derivative tire amino antioxidant 6PPD urban environments, has surged. While several studies have found that quinone exhibits acute, reproductive, behavioral as well mutagenicity hepatotoxicity aquatic terrestrial animals, its environmental exposure data are fragmented lack coherence across source-to-exposure continuum, making it difficult to use for risk assessment regulatory purposes. The present work developed an aggregate pathway (AEP) framework integrate data. An AEP network was atmospheric deposition from wear Pearl River Delta, which led human exposure. research organized, visualized, evaluated with pertinent knowledge gaps identified using weight evidence assessment. Eight key states were identified, only two having high confidence levels three low levels. Empirical support transitional relationships decreased High Low source target site, indicating urgent need downstream mechanistic proposed integrated diverse research, facilitating understanding source-to-outcome development quantitative predictive models future regulation.
Язык: Английский