Study on the Effects and Mechanism of Corilagin on A2780 Cell Apoptosis DOI Open Access
Ziyang Xu,

Yu-Han Jiang,

Tian-tian Shan

и другие.

Опубликована: Авг. 8, 2024

Previous studies found that corilagin inhibits the growth of many cancer cells. Ovarian is deadliest gynecological malignancy, but research on effects ovarian limited. This experiment aims to explore impact A2780 cell apoptosis and its mechanism action evaluate prospects in treating cancer. Corilagin significantly affects cycle, reducing proportion G0/G1 G2/M phase cells blocking them S phase. at low concentrations can cause apoptosis, mitochondrial membrane potential decline, calcium influx. After were stained with Acridine Orange, autophagosomes observed under a fluorescence microscope increased increase concentration. The results transcriptome sequencing showed effect could differential expression apoptosis-related genes concentrated PI3K-AKT pathway. qPCR P53 Bax while BCL-2 decreased. expressions apoptotic factors caspase-9, caspase-3, p53-upregulated modulator (PUMA), cytochrome C after corilagin, indicating induce apoptosis. effectively inhibit proliferation cells, cycle arrest, Moreover, it trigger autophagy has vitro antitumor effects. It promising drug for through PI3K/P53

Язык: Английский

Study on the Effects and Mechanism of Corilagin on A2780 Cell Apoptosis DOI Open Access
Ziyang Xu,

Yu-Han Jiang,

Tian-tian Shan

и другие.

Опубликована: Авг. 8, 2024

Previous studies found that corilagin inhibits the growth of many cancer cells. Ovarian is deadliest gynecological malignancy, but research on effects ovarian limited. This experiment aims to explore impact A2780 cell apoptosis and its mechanism action evaluate prospects in treating cancer. Corilagin significantly affects cycle, reducing proportion G0/G1 G2/M phase cells blocking them S phase. at low concentrations can cause apoptosis, mitochondrial membrane potential decline, calcium influx. After were stained with Acridine Orange, autophagosomes observed under a fluorescence microscope increased increase concentration. The results transcriptome sequencing showed effect could differential expression apoptosis-related genes concentrated PI3K-AKT pathway. qPCR P53 Bax while BCL-2 decreased. expressions apoptotic factors caspase-9, caspase-3, p53-upregulated modulator (PUMA), cytochrome C after corilagin, indicating induce apoptosis. effectively inhibit proliferation cells, cycle arrest, Moreover, it trigger autophagy has vitro antitumor effects. It promising drug for through PI3K/P53

Язык: Английский

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