Building Up a Human Ovarian Antioxidant ceRNA Network, OvAnOx: A Bioinformatic Perspective for Research on Redox-Related Ovarian Functions and Dysfunctions DOI Open Access
Carla Tatone, Giovanna Di Emidio, Rosalia Battaglia

и другие.

Опубликована: Авг. 12, 2024

The ovary is the major determinant of female reproductive health. Ovarian functions are mainly related to primordial follicle pool, which gradually loss with aging. aging and dysfunctions share oxidative stress as common underlying mechanism. ROS signaling essential for normal ovarian processes yet can contribute various disorders when disrupted. Therefore, balance in redox system crucial proper functions. In present study, by focusing on mRNAs ncRNAs described taking into account only validated ncRNA interactions, we built up an antioxidant ceRNA network, namely OvAnOx ceRNA, composed 5 (SOD1, SOD2, CAT, PRDX3, GR), 10 miRNAs lncRNAs (XIST, FGD5-AS1, MALAT1, NEAT1, SNHG1). Our bioinformatic analysis indicated that components not defence, but also involved other Indeed, enzymes encoded mRNA operate within a regulatory network impacts reserve, dynamics, oocyte maturation pathological conditions. represents promising tool unravel complex dialogue between potential signalling pathways health, diseases.

Язык: Английский

Building Up a Human Ovarian Antioxidant ceRNA Network, OvAnOx: A Bioinformatic Perspective for Research on Redox-Related Ovarian Functions and Dysfunctions DOI Open Access
Carla Tatone, Giovanna Di Emidio, Rosalia Battaglia

и другие.

Опубликована: Авг. 12, 2024

The ovary is the major determinant of female reproductive health. Ovarian functions are mainly related to primordial follicle pool, which gradually loss with aging. aging and dysfunctions share oxidative stress as common underlying mechanism. ROS signaling essential for normal ovarian processes yet can contribute various disorders when disrupted. Therefore, balance in redox system crucial proper functions. In present study, by focusing on mRNAs ncRNAs described taking into account only validated ncRNA interactions, we built up an antioxidant ceRNA network, namely OvAnOx ceRNA, composed 5 (SOD1, SOD2, CAT, PRDX3, GR), 10 miRNAs lncRNAs (XIST, FGD5-AS1, MALAT1, NEAT1, SNHG1). Our bioinformatic analysis indicated that components not defence, but also involved other Indeed, enzymes encoded mRNA operate within a regulatory network impacts reserve, dynamics, oocyte maturation pathological conditions. represents promising tool unravel complex dialogue between potential signalling pathways health, diseases.

Язык: Английский

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