Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson’s Disease DOI Open Access
Matthew Miller,

Harold E. Landis,

Robert E. Miller

и другие.

Опубликована: Авг. 14, 2024

Intercellular adhesion molecule 1 (ICAM-1/CD54), a transmembrane glycoprotein, has been considered as one of the most important molecules during leukocyte recruitment. It is encoded by ICAM1 gene and plays central role in inflammation. It’s crucial many inflammatory diseases such ulcerative colitis rheumatoid arthritis are well established. Given that neuroinflammation, underscored microglial activation, key element neurodegenerative Parkinson’s disease (PD), we investigated whether ICAM-1 this progressive neurological condition if so, elucidate underpinning mechanisms. Specifically, were interested potential interaction between ICAM-1, glial cells ferroptosis, an iron-dependent form cell death recently implicated PD. We conclude there exist direct indirect (via T cells) influences on ferroptosis further elucidation these interactions can suggest novel intervention for devastating disease.

Язык: Английский

Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson’s Disease DOI Open Access
Matthew Miller,

Harold E. Landis,

Robert E. Miller

и другие.

Опубликована: Авг. 14, 2024

Intercellular adhesion molecule 1 (ICAM-1/CD54), a transmembrane glycoprotein, has been considered as one of the most important molecules during leukocyte recruitment. It is encoded by ICAM1 gene and plays central role in inflammation. It’s crucial many inflammatory diseases such ulcerative colitis rheumatoid arthritis are well established. Given that neuroinflammation, underscored microglial activation, key element neurodegenerative Parkinson’s disease (PD), we investigated whether ICAM-1 this progressive neurological condition if so, elucidate underpinning mechanisms. Specifically, were interested potential interaction between ICAM-1, glial cells ferroptosis, an iron-dependent form cell death recently implicated PD. We conclude there exist direct indirect (via T cells) influences on ferroptosis further elucidation these interactions can suggest novel intervention for devastating disease.

Язык: Английский

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