Опубликована: Авг. 20, 2024

As the global population ages, prevalence of neurodegenerative diseases has become a major public health concern. The adoption less sedentary lifestyle been shown to have beneficial effect on cognitive decline, but molecular mechanisms responsible are clear. Here we provide detailed analysis complex molecular, cellular, and systemic underlying age-related decline how choices influence these processes. A review evidence from animal models, human studies, postmortem analyses emphasizes importance integrating physical exercise with cognitive, multisensory, motor stimulation as part multifaceted approach mitigating decline. We highlight potential non-pharmacological interventions address key aging hallmarks—such genomic instability, telomere attrition, neuroinflammation—and underscore need for comprehensive personalized strategies promote resilience healthy aging.

Язык: Английский