International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1518 - 1518

Опубликована: Фев. 11, 2025

Colorectal cancer progresses through a well-defined adenoma–carcinoma sequence (ACS), which is pivotal for early detection and intervention. While ACS-based surveillance has been instrumental, its reliance on tissue sampling limits accurate staging. Liquid biopsies, including circulating tumor DNA (ctDNA) extracellular RNA, have emerged as non-invasive alternatives, yet they primarily detect genetic alterations or passive RNA release rather than active biological processes. Thus, there need biomarkers that reflect real-time immune responses tumor–microenvironment interactions during ACS progression. This study aimed to identify associated with by analyzing blood samples from 160 individuals across five groups: colorectal cancer, advanced adenoma, non-advanced symptomatic non-disease control, healthy control. sequencing coupled gene ontology protein–protein interaction analyses identified stage-specific transcripts. Notably, IFI27 was linked the control group, DEFA4 adenoma MPO CD177 group. These findings suggest colorectal-cancer-related markers host progression, supporting their potential role in diagnoses. By addressing critical gaps detection, this advances utility of liquid biopsies screening clinical management.

Язык: Английский