Advances in Ferroptosis Research: A Comprehensive Review of Mechanism Exploration, Drug Development, and Disease Treatment
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 334 - 334
Опубликована: Фев. 26, 2025
In
recent
years,
ferroptosis,
as
an
emerging
modality
of
programmed
cell
death,
has
captured
significant
attention
within
the
scientific
community.
This
comprehensive
review
meticulously
canvasses
pertinent
literature
past
few
spanning
multiple
facets.
It
delves
into
intricate
mechanisms
underpinning
tracks
evolution
its
inducers
and
inhibitors,
dissects
roles
in
a
diverse
array
diseases,
well
resultant
therapeutic
implications.
A
profound
exploration
is
conducted
functional
ferroptosis-related
molecules,
intracellular
pathways,
metabolic
cascades,
signaling
transduction
routes.
Novel
ferroptosis
inhibitors
are
introduced
detail,
covering
their
design
blueprints,
synthetic
methodologies,
bioactivity
profiles.
Moreover,
exhaustive
account
provided
regarding
involvement
malignancies,
neurodegenerative
disorders,
cardiovascular
ailments,
other
pathologies.
By
highlighting
pivotal
status
potential
regimens
various
this
aspires
to
furnish
thorough
reference
framework
for
future
investigations
clinical
translations
domain.
Язык: Английский
Sex-Biased Associations of Circulating Ferroptosis Inhibitors with Reduced Lipid Peroxidation and Better Neurocognitive Performance in People with HIV
Опубликована: Авг. 24, 2024
Ferroptosis
is
implicated
in
viral
neuropathogenesis
and
may
underlie
HIV-associated
neurocognitive
impairment
(NCI).
Emerging
data
also
suggest
differences
brain
iron
transport
by
sex.
We
hypothesized
that
circulating
ferritins
inhibit
ferroptosis
associate
with
function
NCI
people
HIV
(PWH)
a
sex-biased
manner.
Serum
ferritin
heavy-chain-1
(Fth-1),
light-chain
(Ftl),
urinary
F2-isoprostanes
(uF2-isoPs,
specific
lipid
peroxidation
marker)
were
quantified
324
PWH
(including
61
women)
serial
global
(NPZ4)
domain-specific
testing.
Biomarker
associations
test
scores
evaluated
multivariable
regression;
correlations
uF2-isoPs
assessed.
Higher
Ftl
Fth-1
associated
less
all
(adjusted
odds
ratios
0.53,
95%
Confidence
Interval
(95%
CI)
0.36-0.79
0.66,
CI
0.45-0.97,
respectively).
In
women,
higher
better
NPZ-4
(Ftl:
adjusted
beta
(β)=0.15,
0.02-0.29;
Ftl-by-sex
βinteraction=0.32,
p=0.047)
scores.
Effects
on
performance
persisted
for
up
to
5
years.
Levels
of
both
correlated
inversely
women
rho=-0.47,
p<0.001).
Circulating
exert
sustained,
neuroprotective
effects
PWH,
possibly
protecting
against
iron-mediated
(ferroptosis).
Larger
studies
are
needed
confirm
the
observed
sex
further
delineate
underlying
mechanisms.
Язык: Английский