Опубликована: Авг. 27, 2024
In this contribution, the propylamine-functionalized cellulose (Cell-Pr-NH2) was employed as catalyst in three-component reaction between hydroxylamine hydrochloride, various type of aryl/heteroaryl aldehydes, ethyl acetoacetate/ethyl 4-chloroacetoacetate/ or 3-oxohexanoate. The results these experiments were formation 3,4-disubstituted isoxazol-5(4H)-one heterocycles. desired five-membered heterocyclic compounds obtained good to high yields at room temperature. investigation different solvents led us conclusion that water is best solvent perform current one-pot, reactions. Attempts find optimum loading clearly showed 14 mg Cell-Pr-NH2 seems be sufficient carry out This method has highlighted some principles green chemistry including less waste generation, atom economy, use an environmentally friendly solvent, and energy saving. Purification without chromatographic methods, mild conditions, simple work-up, low-cost medium, saving time, obtainable precursors are other notable features one-pot fashion.
Язык: Английский