Therapy of Non-Diabetic Foot Infections after Orthopedic Foot and Ankle Surgery: The Duration Of Post-Debridement Antibiotic Treatment Does Not Alter Failure Risk DOI Open Access

M Scherer,

Laura Soldevila‐Boixader, İnci Yıldız

и другие.

Опубликована: Авг. 29, 2024

Whereas there is an increasing number of scientific publications investigating the optimal anti-biotic treatment for diabetic foot infections, we are lacking corresponding data in adult non-diabetic (postsurgical) infection population. We therefore established one largest single-center databases on this topic and retrospectively investigate failures a combined sur-gical antibiotic therapy surgical site infections. Overall, 17.4% episodes expe-rienced any therapeutic failures; especially among infected ankle prostheses. In contrast, neither age, biological sex, pathogens, duration post-debridement treatment, debridement, or use negative-pressure wound care could alter failure risk. multivariate logistic regression analyses, postsur-gical was completely indifferent (as continuous variable with odds ratio 1.0, 95% confidence interval 0.96-1.03), when stratified into inter-tertiary groups. Our results poten-tially enable shorter applications systemic antibiotics favor better stewardship Consecutive prospective-randomized trials under way to identify eligible patient populations potentially durations infections after elective surgery.

Язык: Английский

Therapy of Non-Diabetic Foot Infections after Orthopedic Foot and Ankle Surgery: The Duration Of Post-Debridement Antibiotic Treatment Does Not Alter Failure Risk DOI Open Access

M Scherer,

Laura Soldevila‐Boixader, İnci Yıldız

и другие.

Опубликована: Авг. 29, 2024

Whereas there is an increasing number of scientific publications investigating the optimal anti-biotic treatment for diabetic foot infections, we are lacking corresponding data in adult non-diabetic (postsurgical) infection population. We therefore established one largest single-center databases on this topic and retrospectively investigate failures a combined sur-gical antibiotic therapy surgical site infections. Overall, 17.4% episodes expe-rienced any therapeutic failures; especially among infected ankle prostheses. In contrast, neither age, biological sex, pathogens, duration post-debridement treatment, debridement, or use negative-pressure wound care could alter failure risk. multivariate logistic regression analyses, postsur-gical was completely indifferent (as continuous variable with odds ratio 1.0, 95% confidence interval 0.96-1.03), when stratified into inter-tertiary groups. Our results poten-tially enable shorter applications systemic antibiotics favor better stewardship Consecutive prospective-randomized trials under way to identify eligible patient populations potentially durations infections after elective surgery.

Язык: Английский

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