Maternal Obesity Alters Placental and Umbilical Cord Plasma Oxidative Stress, a Cross-Sectional Study

Опубликована: Авг. 30, 2024

Maternal obesity has been found to be impaired oxidative status in placenta and newborn which can lead adverse pregnancy outcomes long-term influence on metabolic programming the offspring. This study aimed investigate role of maternal umbilical cord plasma placental adaptation. (n=20) defined as pre-pregnancy BMI ≥ 25 kg/m2 lean < were recruited into this study. Both groups matched by gestational age at delivery. blood, blood tissue collected assess nutritional content (cholesterol, triglyceride, protein), stress marker (MDA protein carbonyl) antioxidant activity (SOD catalase). Placenta expression (SOD2, catalase, UCP2 Nrf2) was evaluated western blot analysis. Catalase significantly increased group (p = 0.0200) with an trend MDA carbonyl levels. Umbilical catalase compared that 0.0462, 0.0485, 0.0348, respectively). Although analysis exhibited significant decreased SOD2 0.0169) 0.0067), accompanied Nrf2 downregulation 0.0453). An mitochondrial expressions observed 0.0143). Hence, our provided evidence is associated fetal parallel expression.

Язык: Английский

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Excessive Weight Gain During Pregnancy Increased Ponoxarase 1 Level in Neonatal Cord Blood

Antioxidants, Год журнала: 2025, Номер 14(1), С. 105 - 105

Опубликована: Янв. 17, 2025

Maternal obesity is increasingly recognized as a risk factor for adverse fetal outcomes, primarily through its association with heightened oxidative stress. This study aimed to evaluate stress markers in umbilical cord blood of neonates born obese mothers. Sixty-three pregnant women, who were normal weight at the start pregnancy but classified term, included. Umbilical samples collected immediately post-delivery and analyzed serum (total oxidant status (TOS), total antioxidant (TAS), paraoxanase (PON), aryl esterase, thiol, catalase activities). Protein interaction networks generated using Cytoscape (v3.10.3), overlapping proteins further functional annotations ShinyGO (0.80). The top ten significantly enriched pathways identified false discovery rate (FDR) threshold <0.05. Significant associations found between maternal BMI change paraoxonase 1 (PON1) levels blood, while no correlation was observed other status) status, catalase). Additionally, analysis showed significant relationship gestational age, not demographic or clinical features. A 24 common protein interactors associated PON1, obesity, identified. Functional annotation revealed enrichment oxidoreductase activities, along involved insulin resistance, AGE-RAGE signaling, atherosclerosis. may specifically affect PON1 activity, potentially serving compensatory response neonates, suggesting possible biomarker stress-related metabolic disturbances mothers, implications monitoring managing outcomes populations.

Язык: Английский

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Oxidative Stress and Antioxidant Status in Pregnant Women with Gestational Diabetes Mellitus and Late-Onset Complication of Pre-Eclampsia

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3605 - 3605

Опубликована: Апрель 11, 2025

Oxidative stress is a critical factor in the onset of gestational diabetes and its associated complication, pre-eclampsia. This study aimed to evaluate (1) reactive oxygen species, nitrogen superoxide radical levels as indicators oxidative stress, (2) lipid protein oxidation, (3) antioxidant enzyme activity, (4) cytokine production pregnant women with diabetes, well those both pre-eclampsia, comparing these biomarkers mellitus. The categorized patients mellitus into two groups based on presence new-onset hypertension, measured twice every four hours, 24 h urine test showing 300 mg/day or ≥1+ proteinuria detected via visual dipstick at ≥20 weeks gestation. These were compared normotensive patients. findings revealed that pre-eclampsia exhibited significantly elevated production, oxidation end products women. Additionally, showed reduced nitric oxide (•NO) levels, impaired NO synthase systems (eNOS iNOS), decreased activities (p < 0.05). results indicate are unable counteract effectively. underscores compromised status contributing complications. provide insights pathogenesis subsequent role resulting Measuring inflammatory could help early detection prediction gestational-diabetes-related complications

Язык: Английский

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Exploratory Evaluation of Circulating Microbiota-Derived Corisin Levels in Women with Adverse Pregnancy Outcomes

Antioxidants, Год журнала: 2025, Номер 14(6), С. 670 - 670

Опубликована: Май 31, 2025

Preterm birth and low weight remain major contributors to neonatal morbidity mortality, yet the underlying mechanisms are not fully understood. Maternal microbiota has been implicated in adverse pregnancy outcomes, but key mediators unidentified. We previously showed that microbiota-derived peptide corisin induces epithelial apoptosis via mitochondrial membrane depolarization reactive oxygen species accumulation. In this retrospective preliminary study, we evaluated association between maternal serum levels outcomes 84 eligible women. Among them, 10 experienced preterm birth, 22 delivered low-birth-weight infants. Corisin were significantly elevated these groups compared with women full-term, normal-weight deliveries. was associated increased tissue factor, while correlated higher thrombin–antithrombin complex soluble thrombomodulin lower fibrinogen levels. concentrations negative correlations BMI, length, estimated fetal weight. Positive observed corisin, myeloperoxidase, several coagulation markers. These findings suggest may reflect involving oxidative stress activation. Further investigation is warranted clarify its potential role as a biomarker complications.

Язык: Английский

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