Exploring the biological mechanism and clinical value of perineural invasion in pancreatic cancer
Cancer Letters,
Год журнала:
2025,
Номер
unknown, С. 217515 - 217515
Опубликована: Янв. 1, 2025
Язык: Английский
Exploring the impact of PDGFD in osteosarcoma metastasis through single-cell sequencing analysis
Cellular Oncology,
Год журнала:
2024,
Номер
47(5), С. 1715 - 1733
Опубликована: Апрель 23, 2024
The
overall
survival
rate
for
metastatic
osteosarcoma
hovers
around
20%.
Responses
to
second-line
chemotherapy,
targeted
therapies,
and
immunotherapies
have
demonstrated
limited
efficacy
in
osteosarcoma.
Our
objective
is
validate
differentially
expressed
genes
signaling
pathways
between
non-metastatic
osteosarcoma,
employing
single-cell
RNA
sequencing
(scRNA-seq)
additional
functional
investigations.
We
aim
enhance
comprehension
of
mechanisms
potentially
unveil
a
therapeutic
target.
Язык: Английский
Spatial transcriptomics reveals unique metabolic profile and key oncogenic regulators of cervical squamous cell carcinoma
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Дек. 31, 2024
As
a
prevalent
and
deadly
malignant
tumor,
the
treatment
outcomes
for
late-stage
patients
with
cervical
squamous
cell
carcinoma
(CSCC)
are
often
suboptimal.
Previous
studies
have
shown
that
tumor
progression
is
closely
related
metabolism
microenvironment
reshaping,
disruptions
in
energy
playing
critical
role
this
process.
To
delve
deeper
into
understanding
of
CSCC
development,
our
research
focused
on
analyzing
metabolic
characteristics
across
different
regions
tissue.
Язык: Английский