Obeticholic Acid Inhibits Anxiety via Alleviating Gut Microbiota-Mediated Microglia Accumulation in the Brain of High-Fat High-Sugar Diet Mice

Nutrients, Год журнала: 2021, Номер 13(3), С. 940 - 940

Опубликована: Март 15, 2021

Anxiety is one of the complications metabolic disorders (MDs). Obeticholic acid (OCA), bile acids (BAs) derivative, a promising agent for improving MDs in association with gut dysbiosis. Yet, its protective effect on MDs-driven anxiety remains unknown. Here, we assessed serum biochemical parameters and behavioral performance by open field Morris water maze tests HFHS diet-induced mice after OCA intervention nine 18 weeks. Moreover, antibiotics microbial depletion was conducted simultaneously. We found that treatment inhibited initiation progression diet-MDs via microbiota–BAs–brain axis: decreased neuroinflammatory microglia IL-1β expression hippocampus, reversed intestinal barrier dysfunction proinflammatory LPS to normal level, modified community, including known anxiety-related Rikenellaceae Alistipes, improved metabolites especially increased BAs feces circulation. OCA-reversed taurocholate linked disordered lipid indole derivatives as network analysis. Additionally, also anxiety, microgliosis enrichment experimental mice. Together, these findings provide axis novel therapeutic target MDs-associated neuropsychiatric disorders.

Язык: Английский

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Catalpol Exerts Antidepressant-Like Effects by Enhancing Anti-oxidation and Neurotrophy and Inhibiting Neuroinflammation via Activation of HO-1

Neurochemical Research, Год журнала: 2022, Номер 47(10), С. 2975 - 2991

Опубликована: Июнь 6, 2022

Язык: Английский

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Exploratory studies of the antidepressant effect of Cordyceps sinensis polysaccharide and its potential mechanism

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 277, С. 134281 - 134281

Опубликована: Июль 29, 2024

Язык: Английский

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Relationship Between Depression and Epigallocatechin Gallate from the Perspective of Gut Microbiota: A Systematic Review

Nutrients, Год журнала: 2025, Номер 17(2), С. 259 - 259

Опубликована: Янв. 12, 2025

Depression, a serious mental illness, is characterized by high risk, incidence, persistence, and tendency to relapse, posing significant burden on global health. The connection between depression gut microbiota an emerging field of study in psychiatry neuroscience. Understanding the gut–brain axis pivotal for understanding pathogenesis treatment depression. Gut microbes influence depression-like behaviors impacting hypothalamic–pituitary–adrenal (HPA), monoamine neurotransmitters, immune responses, cell signaling, metabolic pathways. Tea, widely used clinical practice improve neuropsychiatric disorders, contains Epigallocatechin gallate (EGCG), major ingredient green tea, which effectively regulates intestinal flora. This review examined risks causes depression, complications associated with flora, their role development how EGCG may alleviate through interactions other mechanisms.

Язык: Английский

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Dorsal bed nucleus of the stria terminalis GABA neurons are necessary for chronic unpredictable stress-induced depressive behaviors in adolescent male mice

Journal of Psychiatric Research, Год журнала: 2025, Номер 182, С. 347 - 357

Опубликована: Янв. 18, 2025

Язык: Английский

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