Current status and future trends of the global burden of MASLD

Trends in Endocrinology and Metabolism, Год журнала: 2024, Номер 35(8), С. 697 - 707

Опубликована: Фев. 29, 2024

Язык: Английский

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Recompensation in cirrhosis: unravelling the evolving natural history of nonalcoholic fatty liver disease

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2023, Номер 21(1), С. 46 - 56

Опубликована: Окт. 5, 2023

Язык: Английский

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Steatotic liver disease, MASLD and risk of chronic kidney disease

Diabetes & Metabolism, Год журнала: 2023, Номер 50(1), С. 101506 - 101506

Опубликована: Дек. 21, 2023

With the rising tide of fatty liver disease related to metabolic dysfunction worldwide, association this common with chronic kidney (CKD) has become increasingly evident. In 2020, more inclusive term dysfunction-associated (MAFLD) was proposed replace old nonalcoholic (NAFLD). 2023, a modified Delphi process led by three large pan-national associations. There consensus change nomenclature and definition include presence at least one five cardiometabolic risk factors as diagnostic criteria. The name chosen NAFLD steatotic (MASLD). from MAFLD then MASLD resulted in reappraisal epidemiological trends associations developing CKD. observed between MAFLD/MASLD CKD our understanding that can be an epiphenomenon linked underlying support notion individuals are substantially higher incident than those without MASLD. This narrative review provides overview literature on (a) evolution criteria for diagnosing highly prevalent disease, (b) evidence linking CKD, (c) mechanisms which (and strongly MASLD) may increase (d) potential drug treatments benefit both

Язык: Английский

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An international multidisciplinary consensus on pediatric metabolic dysfunction-associated fatty liver disease

Med, Год журнала: 2024, Номер 5(7), С. 797 - 815.e2

Опубликована: Апрель 26, 2024

Язык: Английский

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MAFLD criteria are better than MASLD criteria at predicting the risk of chronic kidney disease

Annals of Hepatology, Год журнала: 2024, Номер 29(5), С. 101512 - 101512

Опубликована: Май 6, 2024

Fatty liver disease is a multisystem disease. Metabolic dysfunction-associated fatty (MAFLD) more accurate indicator of chronic kidney (CKD) than nonalcoholic (NAFLD). However, the relationship between recently defined metabolic steatotic (MASLD) and CKD currently unclear. The objective this cross-sectional study was to investigate prevalence albuminuria among individuals diagnosed with either MAFLD or MASLD.

Язык: Английский

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Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease

Nature Medicine, Год журнала: 2024, Номер unknown

Опубликована: Дек. 9, 2024

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by an excess of lipids, mainly triglycerides, in the and components metabolic syndrome, which can lead to cirrhosis cancer. While there solid epidemiological evidence that MASLD clusters with cardiometabolic disease, several leading genetic risk factors for do not increase cardiovascular suggesting no causal relationship between derangement. In this work, we leveraged measurements visceral adiposity identifying 27 previously unknown loci associated ( n = 36,394), six replicated four independent cohorts 3,903). Next, generated two partitioned polygenic scores based on presence lipoprotein retention liver. The suggest at least distinct types MASLD, one confined resulting a more aggressive systemic results higher disease. These findings shed light heterogeneity have potential improve prediction clinical trajectories inform precision medicine approaches.

Язык: Английский

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Guideline for the Prevention and Treatment of Metabolic Dysfunction-associated Fatty Liver Disease (Version 2024)

Journal of Clinical and Translational Hepatology, Год журнала: 2024, Номер 000(000), С. 000 - 000

Опубликована: Ноя. 4, 2024

With the rising epidemic of obesity, metabolic syndrome, and type 2 diabetes mellitus in China, dysfunction-associated non-alcoholic fatty liver disease has become most prevalent chronic disease. This condition frequently occurs Chinese patients with alcoholic hepatitis B. To address impending public health crisis its underlying issues, Society Hepatology Medical Association convened a panel clinical experts to revise update "Guideline prevention treatment (2018, China)". The new edition, titled for (Version 2024)", offers comprehensive recommendations on key including screening monitoring, diagnosis evaluation, treatment, follow-up steatotic Metabolic is now preferred English term used interchangeably Additionally, guideline emphasizes importance multidisciplinary collaboration among hepatologists other specialists manage cardiometabolic disorders effectively.

Язык: Английский

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The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease

Hepatology International, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Язык: Английский

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Hepatocytic ballooning in non‐alcoholic steatohepatitis: Dilemmas and future directions

Liver International, Год журнала: 2023, Номер 43(6), С. 1170 - 1182

Опубликована: Апрель 5, 2023

Hepatocytic ballooning is a key histological feature in the diagnosis of non-alcoholic steatohepatitis (NASH) and an essential component two most widely used scoring systems for diagnosing staging fatty liver disease (NAFLD) [namely, NAFLD activity score (NAS), steatosis, fibrosis (SAF) system]. As result increasing incidence NASH globally, diagnostic challenges hepatocytic are unprecedented. Despite clear pathological concept ballooning, there still assessing 'real life' situations. can be confused with cellular oedema microvesicular steatosis. Significant inter-observer variability does exist presence severity ballooning. In this review article, we describe underlying mechanisms associated Specifically, discuss increased endoplasmic reticulum stress unfolded protein response, as well rearrangement intermediate filament cytoskeleton, appearance Mallory-Denk bodies activation sonic Hedgehog pathway. We also use artificial intelligence detection interpretation which may provide new possibilities future treatment.

Язык: Английский

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MAFLD as part of systemic metabolic dysregulation

Hepatology International, Год журнала: 2024, Номер 18(S2), С. 834 - 847

Опубликована: Апрель 9, 2024

Язык: Английский

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